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Literature summary extracted from

  • Wilkins-Port, C.E.; Ye, Q.; Mazurkiewicz, J.E.; Higgins, P.J.
    TGF-beta1 + EGF-initiated invasive potential in transformed human keratinocytes is coupled to a plasmin/MMP-10/MMP-1-dependent collagen remodeling axis: role for PAI-1 (2009), Cancer Res., 69, 4081-4091.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.7 additional information active MMP-10 does not cleave collagen type 1 directly, it does activate the collagenase MMP-1, EC 3.4.24.7. The ability of active MMP-10 to superactivate MMP-1 creates a plasmin/MMP-10/MMP-1 proteolytic axis effectively enhances collagen type 1 degradation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.7 GM6001 a broad-spectrum MMP inhibitor Homo sapiens
3.4.24.7 PAI-1 functions as an upstream regulator of a MMP-1-initiated collagenolytic phenotype, it blocks conversion of MMP-1 to its active form. Neutralization of endogenous PAI-1 with function blocking antibodies accelerates both collagenolysis and activation of MMP-1 Homo sapiens
3.4.24.22 GM6001 a broad-spectrum MMP inhibitor Homo sapiens
3.4.24.22 PAI-1 functions as an upstream regulator of a MMP-10-initiated collagenolytic phenotype, it blocks conversion of MMP-10 to its active form. Neutralization of endogenous PAI-1 with function blocking antibodies accelerates both collagenolysis and activation of MMP-10 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.7 additional information Homo sapiens active MMP-10, EC 3.4.24.22, does not cleave collagen type 1 directly, it does activate the collagenase MMP-1 ?
-
 ?
3.4.24.7 Type I collagen + H2O Homo sapiens a plasmin/MMP-10/MMP-1 proteolytic axis effectively enhances collagen type 1 degradation ?
-
 ?
3.4.24.22 additional information Homo sapiens active MMP-10 does not cleave collagen type 1 directly, it does activate the collagenase MMP-1, EC 3.4.24.7. The ability of active MMP-10 to superactivate MMP-1 creates a plasmin/MMP-10/MMP-1 proteolytic axis effectively enhances collagen type 1 degradation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.7 Homo sapiens
-
-
-
3.4.24.22 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.7 proteolytic modification pro-MMP1 is activated by plasmin to active MMP-1 Homo sapiens
3.4.24.22 proteolytic modification pro-MMP-10 is a plasmin substrate Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.7 HaCaT II-4 cell MMP-10 and MMP-1 are up-regulated in HaCaT II-4 cells Homo sapiens
-
3.4.24.7 keratinocyte
-
 Homo sapiens
-
3.4.24.22 commercial preparation
-
 Homo sapiens
-
3.4.24.22 HaCaT II-4 cell MMP-10 and MMP-1 are up-regulated in HaCaT II-4 cells Homo sapiens
-
3.4.24.22 keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.7 additional information active MMP-10, EC 3.4.24.22, does not cleave collagen type 1 directly, it does activate the collagenase MMP-1 Homo sapiens ?
-
 ?
3.4.24.7 Type I collagen + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.7 Type I collagen + H2O a plasmin/MMP-10/MMP-1 proteolytic axis effectively enhances collagen type 1 degradation Homo sapiens ?
-
 ?
3.4.24.22 additional information active MMP-10 does not cleave collagen type 1 directly, it does activate the collagenase MMP-1, EC 3.4.24.7. The ability of active MMP-10 to superactivate MMP-1 creates a plasmin/MMP-10/MMP-1 proteolytic axis effectively enhances collagen type 1 degradation Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.7 collagenase
-
 Homo sapiens
3.4.24.7 matrix metalloproteinase-1
-
 Homo sapiens
3.4.24.7 MMP-1
-
 Homo sapiens
3.4.24.22 Matrix metalloproteinase-10
-
 Homo sapiens
3.4.24.22 MMP-10
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.24.7 Homo sapiens enhanced collagen degradation, in case of epithelial-to-mesenchymal transition stimulated by transforming growth factor-beta as well as epidermal growth factor receptor, is coupled to a significant increase in matrix metalloproteinase MMP-1 expression and is involved a proteolytic axis composed of plasmin, MMP-10, ec 3.4.24.22, and MMP-1 up
3.4.24.22 Homo sapiens enhanced collagen degradation, in case of epithelial-to-mesenchymal transition stimulated by transforming growth factor-beta as well as epidermal growth factor receptor, is coupled to a significant increase in matrix metalloproteinase MMP-10 expression and is involved a proteolytic axis composed of plasmin, MMP-10, and MMP-1, ec 3.4.24.7 up

General Information

EC Number General Information Comment Organism
3.4.24.7 physiological function role for MMP-1 in the TGF-beta- and EGF-stimulated collagen remodeling process Homo sapiens
3.4.24.22 physiological function role for MMP-10 in the TGF-beta- and EGF-stimulated collagen remodelling process Homo sapiens