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Literature summary extracted from

  • Cui, S.X.; Qu, X.J.; Gao, Z.H.; Zhang, Y.S.; Zhang, X.F.; Zhao, C.R.; Xu, W.F.; Li, Q.B.; Han, J.X.
    Targeting aminopeptidase N (APN/CD13) with cyclic-imide peptidomimetics derivative CIP-13F inhibits the growth of human ovarian carcinoma cells (2010), Cancer Lett., 292, 153-162.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.2 (S)-2-amino-N-((S)-1-(2-(hydroxyamino)-2-oxoethyl)-2,6-dioxopiperidin-3-yl)-3-phenylpropanamide displays a substantial potential inhibitory effect on APN/CD13 activity more potently than bestatin. In the concentration range of 0.0008-0.5 mM, the mean optical density of APN/CD13 activity is reduced by 30%, 53.1%, 63.1%, 68.5%, and 70.8%, respectively, for a 30 min exposure and 37.2%, 56.7%, 66.5%, 73.8%, and 76.2%, respectively, for a 60 min exposure Homo sapiens
3.4.11.2 bestatin i.e. [2S, 3R]-3-amino-2-hydroxy-(4-phenylbutanoyl)-L-leucine Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.2 cell surface
-
 Homo sapiens 9986
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.2 Zn2+ APN is a Zn2+-dependent ectopeptidase Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.2 ES-2 cell has high levels of APN/CD13 Homo sapiens
-
3.4.11.2 HRA cell had low levels of APN/CD13 Homo sapiens
-
3.4.11.2 ovary cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 L-Leu-4-nitroanilide + H2O
-
 Homo sapiens L-Leu + 4-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.2 aminopeptidase N
-
 Homo sapiens
3.4.11.2 APN
-
 Homo sapiens
3.4.11.2 CD13
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.11.2 Homo sapiens the rates of inhibition of APN expression by 0.004, 0.02, and 0.1 mM (S)-2-amino-N-((S)-1-(2-(hydroxyamino)-2-oxoethyl)-2,6-dioxopiperidin-3-yl)-3-phenylpropanamide are 26%, 59.1%, and 87.7%, respectively. Bestatin (0.1 mM) decreases the expression of APN in ES-2 cells by 62.4% down