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Literature summary extracted from

  • Hausheer, F.H.; Parker, A.R.; Petluru, P.N.; Jair, K.W.; Chen, S.; Huang, Q.; Chen, X.; Ayala, P.Y.; Shanmugarajah, D.; Kochat, H.
    Mechanistic study of BNP7787-mediated cisplatin nephroprotection: modulation of human aminopeptidase N (2011), Cancer Chemother. Pharmacol., 67, 381-391.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.2 2-mercaptoethane sulfonic acid 80% residual activity at 10 mM Homo sapiens
3.4.11.2 bestatin i.e. [(2S, 3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine hydroxide, slow binding inhibitor of APN Homo sapiens
3.4.11.2 additional information neither BNP7787 (i.e. disodium 2,2'-dithio-bis-ethane sulfonate, also named dimesna or Tavocept) nor S-carboxymethyl-L-cysteinyl-glutamate, nor NaCl inhibit human APN Homo sapiens
3.4.11.2 S-carboxymethyl-L-cysteine 33% residual activity at 10 mM Homo sapiens
3.4.11.2 S-carboxymethyl-L-cysteinyl-glycine 57% residual activity at 10 mM Homo sapiens
3.4.11.2 S-carboxymethyl-L-glutathione 75% residual activity at 10 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 L-Leu-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens L-Leu + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.2 aminopeptidase N
-
 Homo sapiens
3.4.11.2 APN
-
 Homo sapiens