EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.2 | BAY 41-2272 | heme-dependent sGC activator | Homo sapiens | |
4.6.1.2 | meso-porphyrin IX | heme-independent activator | Homo sapiens | |
4.6.1.2 | nitric oxide | stimulates activity if sGC, 2.2 nM thrombospondin-1 binds to CD47 and potently inhibits nitric oxide stimulation of sGC | Homo sapiens | |
4.6.1.2 | YC-1 | heme-dependent sGC activator | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.2 | thrombospondin-1 | thrombospondin-1 is a universal inhibitor of sGC, blocking both hemedependent and heme-independent activation | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.6.1.2 | GTP | Homo sapiens | - |
3',5'-cyclic-GMP + diphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.6.1.2 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.6.1.2 | blood platelet | - |
Homo sapiens | - |
4.6.1.2 | blood vessel endothelium | - |
Homo sapiens | - |
4.6.1.2 | vascular smooth muscle cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.6.1.2 | GTP | - |
Homo sapiens | 3',5'-cyclic-GMP + diphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.6.1.2 | sGC | - |
Homo sapiens |
4.6.1.2 | soluble guanylyl cyclase | - |
Homo sapiens |