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Literature summary extracted from

  • Killeen, S.D.; Wang, J.H.; Andrews, E.J.; Redmond, H.P.
    Bacterial endotoxin enhances colorectal cancer cell adhesion and invasion through TLR-4 and NF-kappaB-dependent activation of the urokinase plasminogen activator system (2009), Br. J. Cancer, 100, 1589-1602.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.73 amiloride a selective u-PA inhibitor Homo sapiens
3.4.21.73 WXC-340 a selective u-PA inhibitor Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.73 extracellular the enzyme is secreted by cell cultures to the supernatant Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.73 plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.73 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.73 Caco-2 cell
-
 Homo sapiens
-
3.4.21.73 colorectal cancer cell
-
 Homo sapiens
-
3.4.21.73 SW-480 cell
-
 Homo sapiens
-
3.4.21.73 SW-620 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.73 plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.73 u-PA
-
 Homo sapiens
3.4.21.73 uPA
-
 Homo sapiens
3.4.21.73 Urokinase plasminogen activator
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.21.73 Homo sapiens lipopolysaccharide induces u-PA expression. TLR-4 and NF-kappaB inhibition ameliorates LPS-enhanced u-PA and u-PAR expression, tumour cell vitronectin adhesion and ECM invasion up

General Information

EC Number General Information Comment Organism
3.4.21.73 malfunction inhibition of u-PAR and u-PA attenuates lipopolysaccharid-mediated tumour cell adhesion and invasion Homo sapiens
3.4.21.73 additional information lipopolysaccharide promotes tumour cell ECM adhesion and invasion through activation of the u-PA system in a TLR-4- and NF-kappaB-dependent manner, overview Homo sapiens