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Literature summary extracted from

  • Mattila, E.; Marttila, H.; Sahlberg, N.; Kohonen, P.; Taehtinen, S.; Halonen, P.; Peraelae, M.; Ivaska, J.
    Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase (2010), BMC Cancer, 10, 7.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.48 Mitoxantrone activates isozyme TC45 via a mechanism similar to alpha1-cyt, i.e. integrin alpha1 cytoplasmic tail residues 1164-1179, molecular mechanism, overview Mus musculus
3.1.3.48 additional information interaction between the alpha-cytoplasmic tail of a1beta1 integrin and TCPTP activates TCPTP by disrupting an inhibitory intramolecular bond in TCPTP Mus musculus
3.1.3.48 spermidine activates isozyme TC45 via a mechanism similar to alpha1-cyt, i.e. integrin alpha1 cytoplasmic tail residues 1164-1179, molecular mechanism, overview. Spermidine inhibits serum-induced cell proliferation in a TC45-dependent manner, and regulates EGFR and PDGFRb signalling via TC45 Mus musculus

Application

EC Number Application Comment Organism
3.1.3.48 pharmacology inhibition of the regulatory interaction in TCPTP is a desirable strategy for TCPTP activation and attenuation of oncogenic receptor tyrosine kinase signalling Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.48 additional information interaction between the alpha-cytoplasmic tail of a1beta1 integrin and TCPTP activates TCPTP by disrupting an inhibitory intramolecular bond in TCPTP, screening of screened 64280 small molecules for TCPTP inhibition, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.48 nucleus 45 kDa isozyme Mus musculus 5634
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Mus musculus
-
 isozyme TC45
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.48 endothelial cell
-
 Mus musculus
-
3.1.3.48 fibroblast
-
 Mus musculus
-
3.1.3.48 MEF cell
-
 Mus musculus
-
3.1.3.48 T-lymphocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 6,8-difluoro-4-methylumbelliferyl phosphate + H2O
-
 Mus musculus 6,8-difluoro-4-methylumbelliferol + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 non-receptor protein tyrosine phosphatase
-
 Mus musculus
3.1.3.48 protein tyrosine phosphatase
-
 Mus musculus
3.1.3.48 T-cell protein tyrosine phosphatase
-
 Mus musculus
3.1.3.48 TCPTP
-
 Mus musculus
3.1.3.48 TCPTP/TC45
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.1.3.48 malfunction the enzyme is involved in the negative regulation of several cancer relevant cellular signalling pathways Mus musculus