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Literature summary extracted from
- Proteolytic inactivation of tissue factor pathway inhibitor by bacterial omptins (2009), Blood, 113, 1139-1148.
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.23.49 | Escherichia coli | - |
- |
- |
| 3.4.23.49 | Salmonella enterica | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.23.49 | human tissue factor pathway inhibitor + H2O | it is hypothesized that TFPI evolved sensitivity to proteolytic inactivation by bacterial omptins to potentiate procoagulant responses to bacterial infection which may contribute to the hemostatic imbalance in disseminated intravascular coagulation and other coagulopathies accompanying severe sepsis | Escherichia coli | ? | - |
? |  |
| 3.4.23.49 | human tissue factor pathway inhibitor + H2O | it is hypothesized that TFPI evolved sensitivity to proteolytic inactivation by bacterial omptins to potentiate procoagulant responses to bacterial infection which may contribute to the hemostatic imbalance in disseminated intravascular coagulation and other coagulopathies accompanying severe sepsis | Salmonella enterica | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.23.49 | ompT | - |
Escherichia coli |
| 3.4.23.49 | ompT | - |
Salmonella enterica |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.23.49 | 37 | - |
assay at | Escherichia coli |
| 3.4.23.49 | 37 | - |
assay at | Salmonella enterica |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.23.49 | 7.4 | - |
assay at | Escherichia coli |
| 3.4.23.49 | 7.4 | - |
assay at | Salmonella enterica |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.23.49 | malfunction | using gene deletions, it is demonstrated that bacterial inactivation of tissue factor pathway inhibitor (TFPI) requires omptin expression | Escherichia coli |
| 3.4.23.49 | malfunction | using gene deletions, it is demonstrated that bacterial inactivation of tissue factor pathway inhibitor (TFPI) requires omptin expression | Salmonella enterica |
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