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Literature summary extracted from
- Characterization of the norepinephrine-activation of adenylate cyclase suggests a role in memory affirmation pathways Overexposure to epinephrine inactivates adenylate cyclase, a causal pathway for stress-pathologies (2010), BioSystems, 100, 87-93.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.1 | adrenaline | stimulates adenylate cyclase activity | Rattus norvegicus |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.1 | Ca2+ | calcium entrance in the cell inhibits the enzyme | Rattus norvegicus | |
| 4.6.1.1 | epinephrine | overexposure to epinephrine inactivates adenylate cyclase | Rattus norvegicus | |
| 4.6.1.1 | noradrenaline | adenylate cyclase is almost completely inhibited by 0.5 mM noradrenaline | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.6.1.1 | membrane | - |
Rattus norvegicus | 16020 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.6.1.1 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.6.1.1 | brain cortex | - |
Rattus norvegicus | - |
| 4.6.1.1 | corpus striatum | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.6.1.1 | ATP | - |
Rattus norvegicus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.6.1.1 | adenylate cyclase [ATP pyrophosphate-lyase (cyclizing)] | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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