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Literature summary extracted from
- Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors (2010), Bioorg. Med. Chem., 18, 1244-1251.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.7 | 9-O-[2-(9H-carbazole-4-yloxy)ethyl] berberine bromide | - |
Electrophorus electricus |  |
| 3.1.1.7 | 9-O-[2-(benzotriazole-1-yloxy)ethyl] berberine bromide | - |
Electrophorus electricus | |
| 3.1.1.7 | 9-O-[2-(phenylol-1-yloxy)ethyl] berberine bromide | - |
Electrophorus electricus | |
| 3.1.1.7 | 9-O-[2-(phenylol-1-yloxy)hexyl] berberine bromide | - |
Electrophorus electricus | |
| 3.1.1.7 | 9-O-[3-(9H-carbazole-4-yloxy)propyl] berberine bromide | - |
Electrophorus electricus | |
| 3.1.1.7 | 9-O-[3-(benzotriazole-1-yloxy)propyl] berberine bromide | - |
Electrophorus electricus | |
| 3.1.1.7 | 9-O-[3-(phenylol-1-yloxy)propyl] berberine bromide | - |
Electrophorus electricus | |
| 3.1.1.7 | 9-O-[4-(9H-carbazole-4-yloxy)butyl] berberine bromide | - |
Electrophorus electricus | |
| 3.1.1.7 | 9-O-[4-(benzotriazole-1-yloxy)butyl] berberine bromide | - |
Electrophorus electricus | |
| 3.1.1.7 | 9-O-[4-(phenylol-1-yloxy)butyl] berberine bromide | most potent berberine derivative inhibitor, mixed type inhibition | Electrophorus electricus | |
| 3.1.1.7 | 9-O-[5-(9H-carbazole-4-yloxy)butyl] berberine bromide | - |
Electrophorus electricus | |
| 3.1.1.7 | 9-O-[5-(benzotriazole-1-yloxy)pentyl] berberine bromide | - |
Electrophorus electricus | |
| 3.1.1.7 | 9-O-[5-(phenylol-1-yloxy)pentyl] berberine bromide | - |
Electrophorus electricus | |
| 3.1.1.7 | 9-O-[6-(9H-carbazole-4-yloxy)butyl] berberine bromide | - |
Electrophorus electricus | |
| 3.1.1.7 | 9-O-[6-(benzotriazole-1-yloxy)hexyl] berberine bromide | - |
Electrophorus electricus | |
| 3.1.1.7 | Berberine | competitive inhibition | Electrophorus electricus | |
| 3.1.1.7 | donepezil | - |
Electrophorus electricus | |
| 3.1.1.7 | galanthamine | - |
Electrophorus electricus | |
| 3.1.1.7 | huperzine A | - |
Electrophorus electricus | |
| 3.1.1.7 | additional information | synthesis and biological evaluation of berberine derivatives as potent acetylcholinesterase inhibitors, kinetic and molecular modeling studies, overview | Electrophorus electricus | |
| 3.1.1.7 | tacrine | - |
Electrophorus electricus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.7 | Electrophorus electricus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.7 | commercial preparation | - |
Electrophorus electricus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.7 | acetylcholine chloride + H2O | - |
Electrophorus electricus | acetate + choline chloride | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.7 | AChE | - |
Electrophorus electricus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.7 | 37 | - |
in vitro assay at | Electrophorus electricus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.7 | 8 | - |
in vitro assay at | Electrophorus electricus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.7 | 0.000045 | - |
9-O-[4-(phenylol-1-yloxy)butyl] berberine bromide | pH 8.0, 37°C | Electrophorus electricus | |
| 3.1.1.7 | 0.000289 | - |
Berberine | pH 8.0, 37°C | Electrophorus electricus | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.7 | 0.000052 | - |
pH 8.0, 37°C | Electrophorus electricus | 9-O-[2-(phenylol-1-yloxy)hexyl] berberine bromide | |
| 3.1.1.7 | 0.000097 | - |
pH 8.0, 37°C | Electrophorus electricus | 9-O-[4-(phenylol-1-yloxy)butyl] berberine bromide | |
| 3.1.1.7 | 0.000123 | - |
pH 8.0, 37°C | Electrophorus electricus | 9-O-[3-(phenylol-1-yloxy)propyl] berberine bromide | |
| 3.1.1.7 | 0.000224 | - |
pH 8.0, 37°C | Electrophorus electricus | 9-O-[2-(phenylol-1-yloxy)ethyl] berberine bromide | |
| 3.1.1.7 | 0.000224 | - |
pH 8.0, 37°C | Electrophorus electricus | 9-O-[4-(benzotriazole-1-yloxy)butyl] berberine bromide | |
| 3.1.1.7 | 0.00028 | - |
pH 8.0, 37°C | Electrophorus electricus | 9-O-[5-(benzotriazole-1-yloxy)pentyl] berberine bromide | |
| 3.1.1.7 | 0.000359 | - |
pH 8.0, 37°C | Electrophorus electricus | 9-O-[3-(benzotriazole-1-yloxy)propyl] berberine bromide | |
| 3.1.1.7 | 0.000374 | - |
pH 8.0, 37°C | Electrophorus electricus | Berberine | |
| 3.1.1.7 | 0.000375 | - |
pH 8.0, 37°C | Electrophorus electricus | 9-O-[2-(benzotriazole-1-yloxy)ethyl] berberine bromide | |
| 3.1.1.7 | 0.000398 | - |
pH 8.0, 37°C | Electrophorus electricus | 9-O-[5-(phenylol-1-yloxy)pentyl] berberine bromide | |
| 3.1.1.7 | 0.000515 | - |
pH 8.0, 37°C | Electrophorus electricus | 9-O-[6-(benzotriazole-1-yloxy)hexyl] berberine bromide | |
| 3.1.1.7 | 0.000623 | - |
pH 8.0, 37°C | Electrophorus electricus | galanthamine | |
| 3.1.1.7 | 0.000856 | - |
pH 8.0, 37°C | Electrophorus electricus | 9-O-[4-(9H-carbazole-4-yloxy)butyl] berberine bromide | |
| 3.1.1.7 | 0.00112 | - |
pH 8.0, 37°C | Electrophorus electricus | 9-O-[3-(9H-carbazole-4-yloxy)propyl] berberine bromide | |
| 3.1.1.7 | 0.00123 | - |
pH 8.0, 37°C | Electrophorus electricus | 9-O-[2-(9H-carbazole-4-yloxy)ethyl] berberine bromide | |
| 3.1.1.7 | 0.00168 | - |
pH 8.0, 37°C | Electrophorus electricus | 9-O-[5-(9H-carbazole-4-yloxy)butyl] berberine bromide | |
| 3.1.1.7 | 0.0021 | - |
pH 8.0, 37°C | Electrophorus electricus | 9-O-[6-(9H-carbazole-4-yloxy)butyl] berberine bromide | |
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