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Literature summary extracted from

  • Li, J.; Petrassi, H.; Tumanut, C.; Masick, B.; Trussell, C.; Harris, J.
    Substrate optimization for monitoring cathepsin C activity in live cells (2009), Bioorg. Med. Chem., 17, 1064-1070.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.1 (2S)-2-amino-N-[(1S)-2-(biphenyl-4-yl)-1-cyanoethyl]butanamide
-
 Homo sapiens
3.4.14.1 N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-norvalinamide
-
 Homo sapiens
3.4.14.1 N2-(morpholin-4-ylcarbonyl)-N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-leucinamide
-
 Homo sapiens
3.4.22.1 (2S)-2-amino-N-[(1S)-2-(biphenyl-4-yl)-1-cyanoethyl]butanamide
-
 Homo sapiens
3.4.22.1 N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-norvalinamide
-
 Homo sapiens
3.4.22.1 N2-(morpholin-4-ylcarbonyl)-N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-leucinamide
-
 Homo sapiens
3.4.22.16 (2S)-2-amino-N-[(1S)-2-(biphenyl-4-yl)-1-cyanoethyl]butanamide
-
 Homo sapiens
3.4.22.16 N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-norvalinamide
-
 Homo sapiens
3.4.22.16 N2-(morpholin-4-ylcarbonyl)-N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-leucinamide
-
 Homo sapiens
3.4.22.27 (2S)-2-amino-N-[(1S)-2-(biphenyl-4-yl)-1-cyanoethyl]butanamide
-
 Homo sapiens
3.4.22.27 N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-norvalinamide
-
 Homo sapiens
3.4.22.27 N2-(morpholin-4-ylcarbonyl)-N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-leucinamide
-
 Homo sapiens
3.4.22.38 (2S)-2-amino-N-[(1S)-2-(biphenyl-4-yl)-1-cyanoethyl]butanamide
-
 Homo sapiens
3.4.22.38 N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-norvalinamide
-
 Homo sapiens
3.4.22.38 N2-(morpholin-4-ylcarbonyl)-N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-leucinamide
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.1 Homo sapiens
-
-
-
3.4.22.1 Homo sapiens
-
-
-
3.4.22.16 Homo sapiens
-
-
-
3.4.22.27 Homo sapiens
-
-
-
3.4.22.38 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.1 B-lymphoblastoid cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.1 (H2N-Abu-Homo-Phe)2-rhodamine + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
3.4.14.1 (H2N-fulleroproline-Homo-Phe)2-rhodamine + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
3.4.14.1 (H2N-Leu-Homo-Phe)2-rhodamine + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
3.4.14.1 (H2N-Leu-Leu)2-rhodamine + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
3.4.14.1 (H2N-Nva-(4-phenyl)Phe)2-rhodamine + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
3.4.14.1 (H2N-Nva-Homo-Phe)2-rhodamine + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
3.4.14.1 (H2N-Pro-Homo-Phe)2-rhodamine + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
3.4.14.1 Gly-Phe-7-amido-4-methylcoumarin + H2O assay at pH 5.5, 37°C Homo sapiens Gly-Phe + 7-amino-4-methylcoumarin
-
 ?
3.4.14.1 H2N-Abu-(4-phenyl)Phe-rhodamine-morpholine-4-carboxamide + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
3.4.14.1 H2N-Abu-Homo-Phe-rhodamine-morpholine-4-carboxamide + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
3.4.14.1 H2N-fulleroproline-(3-methyl)Phe-rhodamine-morpholine-4-carboxamide + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
3.4.14.1 H2N-fulleroproline-(4-phenyl)Phe-rhodamine-morpholine-4-carboxamide + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
3.4.14.1 H2N-Leu-(3-methyl)Phe-rhodamine-morpholine-4-carboxamide + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
3.4.14.1 H2N-Nva-(3-methyl)Phe-rhodamine-morpholine-4-carboxamide + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
3.4.22.1 Ac-His-Pro-Val-Lys-7-amido-3-carbamoylmethyl-4-methylcoumarin + H2O assay at pH 5.5, 37°C Homo sapiens Ac-His-Pro-Val-Lys + 7-amino-3-carbamoyl-4-methylcoumarin
-
 ?
3.4.22.16 Arg-7-amido-4-methylcoumarin + H2O assay at pH 5.5, 37°C Homo sapiens L-arginine + 7-amino-4-methylcoumarin
-
 ?
3.4.22.27 Ac-His-Pro-Val-Lys-7-amido-3-carbamoylmethyl-4-methylcoumarin + H2O assay at pH 5.5, 37°C Homo sapiens Ac-His-Pro-Val-Lys + 7-amino-3-carbamoylmethyl-4-methylcoumarin
-
 ?
3.4.22.38 Ac-Lys-His-Pro-Lys-7-amido-3-carbamoylmethyl-4-methylcoumarin + H2O assay at pH 5.5, 37°C Homo sapiens Ac-Lys-His-Pro-Lys + 7-amino-3-carbamoylmethyl-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.14.1 Cat C
-
 Homo sapiens
3.4.14.1 cathepsin C
-
 Homo sapiens
3.4.22.1 cat B
-
 Homo sapiens
3.4.22.1 cathepsin B
-
 Homo sapiens
3.4.22.16 Cat H
-
 Homo sapiens
3.4.22.16 cathepsin H
-
 Homo sapiens
3.4.22.27 Cat S
-
 Homo sapiens
3.4.22.27 cathepsin S
-
 Homo sapiens
3.4.22.38 Cat K
-
 Homo sapiens
3.4.22.38 cathepsin K
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.14.1 37
-
 assay at Homo sapiens
3.4.22.1 37
-
 assay at Homo sapiens
3.4.22.16 37
-
 assay at Homo sapiens
3.4.22.27 37
-
 assay at Homo sapiens
3.4.22.38 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.14.1 5.5
-
 assay at Homo sapiens
3.4.22.1 5.5
-
 assay at Homo sapiens
3.4.22.16 5.5
-
 assay at Homo sapiens
3.4.22.27 5.5
-
 assay at Homo sapiens
3.4.22.38 5.5
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.14.1 0.0000002
-
 N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-norvalinamide
-
 Homo sapiens
3.4.14.1 0.0000015
-
 (2S)-2-amino-N-[(1S)-2-(biphenyl-4-yl)-1-cyanoethyl]butanamide
-
 Homo sapiens
3.4.14.1 0.0018
-
 N2-(morpholin-4-ylcarbonyl)-N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-leucinamide
-
 Homo sapiens
3.4.22.1 additional information
-
 (2S)-2-amino-N-[(1S)-2-(biphenyl-4-yl)-1-cyanoethyl]butanamide value above 0.01 Homo sapiens
3.4.22.1 0.000064
-
 N2-(morpholin-4-ylcarbonyl)-N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-leucinamide
-
 Homo sapiens
3.4.22.1 0.0011
-
 N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-norvalinamide
-
 Homo sapiens
3.4.22.16 0.00014
-
 N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-norvalinamide
-
 Homo sapiens
3.4.22.16 0.0014
-
 N2-(morpholin-4-ylcarbonyl)-N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-leucinamide
-
 Homo sapiens
3.4.22.16 0.0037
-
 (2S)-2-amino-N-[(1S)-2-(biphenyl-4-yl)-1-cyanoethyl]butanamide
-
 Homo sapiens
3.4.22.27 additional information
-
 (2S)-2-amino-N-[(1S)-2-(biphenyl-4-yl)-1-cyanoethyl]butanamide value above 0.01 Homo sapiens
3.4.22.27 additional information
-
 N2-(morpholin-4-ylcarbonyl)-N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-leucinamide value below 0.0000001 Homo sapiens
3.4.22.27 0.0000055
-
 N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-norvalinamide
-
 Homo sapiens
3.4.22.38 0.0000012
-
 N2-(morpholin-4-ylcarbonyl)-N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-leucinamide
-
 Homo sapiens
3.4.22.38 0.00012
-
 N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-norvalinamide
-
 Homo sapiens
3.4.22.38 0.018
-
 (2S)-2-amino-N-[(1S)-2-(biphenyl-4-yl)-1-cyanoethyl]butanamide
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.14.1 0.0001
-
-
 Homo sapiens N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-norvalinamide
3.4.14.1 0.004
-
-
 Homo sapiens N2-(morpholin-4-ylcarbonyl)-N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-leucinamide
3.4.14.1 0.01
-
-
 Homo sapiens (2S)-2-amino-N-[(1S)-2-(biphenyl-4-yl)-1-cyanoethyl]butanamide