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Literature summary extracted from

  • Xu, G.H.; Kim, Y.H.; Chi, S.W.; Choo, S.J.; Ryoo, I.J.; Ahn, J.S.; Yoo, I.D.
    Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa (2010), Bioorg. Med. Chem. Lett., 20, 513-515.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.37 (-)-epigallocatechin-3-gallate
-
 Homo sapiens
3.4.21.37 (E)-6-O-p-coumaroyl scandoside methyl ester an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant Homo sapiens
3.4.21.37 (E)-6-O-p-feruloyl scandoside methyl ester an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant Homo sapiens
3.4.21.37 (E)-6-O-p-methoxycinnamoyl scandoside methyl ester an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant. Molecular docking simulation and structural model for the inhibition of human neutrophil elastase, overview Homo sapiens
3.4.21.37 (Z)-6-O-p-coumaroyl scandoside methyl ester an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant Homo sapiens
3.4.21.37 (Z)-6-O-p-methoxycinnamoyl scandoside methyl ester an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.37 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.37 N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Homo sapiens N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.37 neutrophil elastase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.37 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.37 7.5
-
 assay at Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.21.37 0.0128
-
 pH 7.5, 37°C Homo sapiens (-)-epigallocatechin-3-gallate
3.4.21.37 0.018
-
 pH 7.5, 37°C Homo sapiens (E)-6-O-p-methoxycinnamoyl scandoside methyl ester
3.4.21.37 0.1
-
 pH 7.5, 37°C, above Homo sapiens (Z)-6-O-p-methoxycinnamoyl scandoside methyl ester
3.4.21.37 0.1
-
 pH 7.5, 37°C, above Homo sapiens (E)-6-O-p-feruloyl scandoside methyl ester
3.4.21.37 0.1
-
 pH 7.5, 37°C, above Homo sapiens (E)-6-O-p-coumaroyl scandoside methyl ester
3.4.21.37 0.1
-
 pH 7.5, 37°C, above Homo sapiens (Z)-6-O-p-coumaroyl scandoside methyl ester