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Literature summary extracted from

  • Sandanayaka, V.; Mamat, B.; Bhagat, N.; Bedell, L.; Halldorsdottir, G.; Sigthorsdottir, H.; Andresson, T.; Kiselyov, A.; Gurney, M.; Singh, J.
    Discovery of novel leukotriene A4 inhibitors based on piperidine and piperazine scaffolds (2010), Bioorg. Med. Chem. Lett., 20, 2851-2854.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.6 (2R)-2-([4-[4-(thiophen-2-yl)benzyl]phenoxy]methyl)piperidine
-
 Homo sapiens
3.3.2.6 (2R)-2-([4-[4-(thiophen-3-yl)benzyl]phenoxy]methyl)piperidine
-
 Homo sapiens
3.3.2.6 (2R)-2-([4-[4-(thiophen-3-yl)phenoxy]phenoxy]methyl)piperidine
-
 Homo sapiens
3.3.2.6 (2R)-2-[(4-phenoxyphenoxy)methyl]piperidine
-
 Homo sapiens
3.3.2.6 (2R)-2-[[4-(4-chlorobenzyl)phenoxy]methyl]piperidine
-
 Homo sapiens
3.3.2.6 (2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]-1-(1,2,4-oxadiazol-2(3H)-ylmethyl)piperidine
-
 Homo sapiens
3.3.2.6 (2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]piperidine
-
 Homo sapiens
3.3.2.6 (2R)-2-[[4-(4-fluorophenoxy)phenoxy]methyl]piperidine
-
 Homo sapiens
3.3.2.6 (2R)-2-[[4-(biphenyl-4-yloxy)phenoxy]methyl]piperidine
-
 Homo sapiens
3.3.2.6 (2S)-2-([4-[4-(trifluoromethyl)phenoxy]phenoxy]methyl)piperidine
-
 Homo sapiens
3.3.2.6 (2S)-2-[(4-benzylphenoxy)methyl]piperidine
-
 Homo sapiens
3.3.2.6 (2S)-2-[(4-phenoxyphenoxy)methyl]piperidine
-
 Homo sapiens
3.3.2.6 (2S)-2-[[4-(4-chlorobenzyl)phenoxy]methyl]piperidine
-
 Homo sapiens
3.3.2.6 (2S)-2-[[4-(biphenyl-4-yloxy)phenoxy]methyl]piperidine
-
 Homo sapiens
3.3.2.6 1-benzyl-3-[(4-benzylphenoxy)methyl]piperazine
-
 Homo sapiens
3.3.2.6 2-[(4-benzylphenoxy)methyl]piperazine
-
 Homo sapiens
3.3.2.6 2-[(4-benzylphenoxy)methyl]piperidine
-
 Homo sapiens
3.3.2.6 2-[(4-phenoxyphenoxy)methyl]piperidine
-
 Homo sapiens
3.3.2.6 3-[(2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]piperidin-1-yl]propanoic acid
-
 Homo sapiens
3.3.2.6 4-[(2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]piperidin-1-yl]butanoic acid
-
 Homo sapiens
3.3.2.6 4-[(2S)-2-([4-[4-(thiophen-3-yl)benzyl]phenoxy]methyl)piperidin-1-yl]butanoic acid
-
 Homo sapiens
3.3.2.6 4-[(2S)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]piperidin-1-yl]butanoic acid
-
 Homo sapiens
3.3.2.6 additional information leukotriene A4 inhibitors based on piperidine and piperazine scaffolds, overview Homo sapiens
3.3.2.6 [(2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]piperidin-1-yl]acetic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O Homo sapiens
-
 leukotriene B4
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.6 blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.6 leukotriene A4 hydrolase
-
 Homo sapiens
3.3.2.6 LTA4 hydrolase
-
 Homo sapiens
3.3.2.6 LTA4H
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.3.2.6 0.0000069
-
-
 Homo sapiens (2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]-1-(1,2,4-oxadiazol-2(3H)-ylmethyl)piperidine
3.3.2.6 0.000044
-
-
 Homo sapiens (2R)-2-[(4-phenoxyphenoxy)methyl]piperidine
3.3.2.6 0.000048
-
-
 Homo sapiens (2S)-2-[(4-phenoxyphenoxy)methyl]piperidine
3.3.2.6 0.000049
-
-
 Homo sapiens 4-[(2S)-2-([4-[4-(thiophen-3-yl)benzyl]phenoxy]methyl)piperidin-1-yl]butanoic acid
3.3.2.6 0.000053
-
-
 Homo sapiens 4-[(2S)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]piperidin-1-yl]butanoic acid
3.3.2.6 0.000056
-
-
 Homo sapiens (2R)-2-([4-[4-(thiophen-2-yl)benzyl]phenoxy]methyl)piperidine
3.3.2.6 0.00006
-
-
 Homo sapiens (2R)-2-([4-[4-(thiophen-3-yl)benzyl]phenoxy]methyl)piperidine
3.3.2.6 0.00007
-
-
 Homo sapiens 2-[(4-phenoxyphenoxy)methyl]piperidine
3.3.2.6 0.000093
-
-
 Homo sapiens (2S)-2-([4-[4-(trifluoromethyl)phenoxy]phenoxy]methyl)piperidine
3.3.2.6 0.000093
-
-
 Homo sapiens (2R)-2-([4-[4-(thiophen-3-yl)phenoxy]phenoxy]methyl)piperidine
3.3.2.6 0.000094
-
-
 Homo sapiens (2S)-2-[(4-benzylphenoxy)methyl]piperidine
3.3.2.6 0.000096
-
-
 Homo sapiens (2S)-2-[[4-(biphenyl-4-yloxy)phenoxy]methyl]piperidine
3.3.2.6 0.000106
-
-
 Homo sapiens 4-[(2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]piperidin-1-yl]butanoic acid
3.3.2.6 0.00011
-
-
 Homo sapiens (2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]piperidine
3.3.2.6 0.000114
-
-
 Homo sapiens (2R)-2-[[4-(biphenyl-4-yloxy)phenoxy]methyl]piperidine
3.3.2.6 0.000134
-
-
 Homo sapiens 2-[(4-benzylphenoxy)methyl]piperidine
3.3.2.6 0.000174
-
-
 Homo sapiens (2R)-2-[[4-(4-fluorophenoxy)phenoxy]methyl]piperidine
3.3.2.6 0.000212
-
-
 Homo sapiens 3-[(2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]piperidin-1-yl]propanoic acid
3.3.2.6 0.000315
-
-
 Homo sapiens (2S)-2-[[4-(4-chlorobenzyl)phenoxy]methyl]piperidine
3.3.2.6 0.000342
-
-
 Homo sapiens 2-[(4-benzylphenoxy)methyl]piperazine
3.3.2.6 0.000438
-
-
 Homo sapiens (2R)-2-[[4-(4-chlorobenzyl)phenoxy]methyl]piperidine
3.3.2.6 0.00066
-
-
 Homo sapiens 1-benzyl-3-[(4-benzylphenoxy)methyl]piperazine
3.3.2.6 0.00088
-
-
 Homo sapiens [(2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]piperidin-1-yl]acetic acid

General Information

EC Number General Information Comment Organism
3.3.2.6 metabolism leukotriene A4 hydrolase is a key enzyme in the leukotriene pathway, which hydrolyzes leukotriene A4 to leukotriene B4, a proinflammatory mediator Homo sapiens