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Literature summary extracted from

  • Bonesi, M.; Loizzo, M.R.; Statti, G.A.; Michel, S.; Tillequin, F.; Menichini, F.
    The synthesis and angiotensin converting enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives (2010), Bioorg. Med. Chem. Lett., 20, 1990-1993.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 (2E)-3-(3-amino-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
-
 Oryctolagus cuniculus
3.4.15.1 (2E)-3-(3-fluoro-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
-
 Oryctolagus cuniculus
3.4.15.1 (2E)-3-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
-
 Oryctolagus cuniculus
3.4.15.1 (2E)-3-(3-hydroxy-4-nitrophenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
-
 Oryctolagus cuniculus
3.4.15.1 (2E)-3-(3-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
-
 Oryctolagus cuniculus
3.4.15.1 (2E)-3-(4-hydroxy-3-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
-
 Oryctolagus cuniculus
3.4.15.1 (2E)-3-(4-methoxy-3-nitrophenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
-
 Oryctolagus cuniculus
3.4.15.1 (2E)-3-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
-
 Oryctolagus cuniculus
3.4.15.1 (2E)-3-phenyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
-
 Oryctolagus cuniculus
3.4.15.1 1-methyl-5-phenyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole
-
 Oryctolagus cuniculus
3.4.15.1 2-methoxy-4-[1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-5-yl]phenol
-
 Oryctolagus cuniculus
3.4.15.1 2-methoxy-5-[1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-5-yl]aniline
-
 Oryctolagus cuniculus
3.4.15.1 2-methoxy-5-[1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-5-yl]phenol
-
 Oryctolagus cuniculus
3.4.15.1 5-(3-fluoro-4-methoxyphenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole
-
 Oryctolagus cuniculus
3.4.15.1 5-(3-methoxyphenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole
-
 Oryctolagus cuniculus
3.4.15.1 5-(4-methoxy-3-nitrophenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole
-
 Oryctolagus cuniculus
3.4.15.1 5-(4-methoxyphenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole
-
 Oryctolagus cuniculus
3.4.15.1 5-[1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-5-yl]-2-nitrophenol
-
 Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 commercial preparation
-
 Oryctolagus cuniculus
-
3.4.15.1 lung
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 dansyltriglycine + H2O
-
 Oryctolagus cuniculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.15.1 ACE
-
 Oryctolagus cuniculus
3.4.15.1 angiotensin converting enzyme
-
 Oryctolagus cuniculus
3.4.15.1 angiotensin I-converting enzyme
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.15.1 37
-
 assay at Oryctolagus cuniculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.15.1 0.213
-
 37°C Oryctolagus cuniculus 5-(4-methoxy-3-nitrophenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole
3.4.15.1 0.219
-
 37°C Oryctolagus cuniculus (2E)-3-(3-amino-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
3.4.15.1 0.225
-
 37°C Oryctolagus cuniculus (2E)-3-(4-hydroxy-3-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
3.4.15.1 0.246
-
 37°C Oryctolagus cuniculus (2E)-3-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
3.4.15.1 0.338
-
 37°C Oryctolagus cuniculus (2E)-3-phenyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
3.4.15.1 0.435
-
 37°C Oryctolagus cuniculus 5-(4-methoxyphenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole
3.4.15.1 0.516
-
 37°C Oryctolagus cuniculus (2E)-3-(4-methoxy-3-nitrophenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
3.4.15.1 0.552
-
 37°C Oryctolagus cuniculus (2E)-3-(3-hydroxy-4-nitrophenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
3.4.15.1 0.57
-
 37°C Oryctolagus cuniculus (2E)-3-(3-fluoro-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
3.4.15.1 0.574
-
 37°C Oryctolagus cuniculus (2E)-3-(3-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
3.4.15.1 0.599
-
 37°C Oryctolagus cuniculus 5-[1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-5-yl]-2-nitrophenol
3.4.15.1 0.622
-
 37°C Oryctolagus cuniculus (2E)-3-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
3.4.15.1 0.674
-
 37°C Oryctolagus cuniculus 2-methoxy-4-[1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-5-yl]phenol
3.4.15.1 0.749
-
 37°C Oryctolagus cuniculus 2-methoxy-5-[1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-5-yl]aniline
3.4.15.1 0.762
-
 37°C Oryctolagus cuniculus 2-methoxy-5-[1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-5-yl]phenol
3.4.15.1 0.77
-
 37°C Oryctolagus cuniculus 5-(3-fluoro-4-methoxyphenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole
3.4.15.1 0.805
-
 37°C Oryctolagus cuniculus 1-methyl-5-phenyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole
3.4.15.1 0.889
-
 37°C Oryctolagus cuniculus 5-(3-methoxyphenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole