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Literature summary extracted from

  • Ryu, Y.B.; Park, S.J.; Kim, Y.M.; Lee, J.Y.; Seo, W.D.; Chang, J.S.; Park, K.H.; Rho, M.C.; Lee, W.S.
    SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii (2010), Bioorg. Med. Chem. Lett., 20, 1873-1876.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.69 celastrol competitive inhibitor Severe acute respiratory syndrome-related coronavirus
3.4.22.69 curcumin
-
 Severe acute respiratory syndrome-related coronavirus
3.4.22.69 dihydrocelastrol
-
 Severe acute respiratory syndrome-related coronavirus
3.4.22.69 iguesterin competitive inhibitor Severe acute respiratory syndrome-related coronavirus
3.4.22.69 pristimerin competitive inhibitor Severe acute respiratory syndrome-related coronavirus
3.4.22.69 tingenone competitive inhibitor Severe acute respiratory syndrome-related coronavirus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.69 Severe acute respiratory syndrome-related coronavirus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.69 commercial preparation Severe acute respiratory syndrome-related coronavirus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.69 DABCYL-Lys-Asn-Ser-Thr-Leu-Gln-Ser-Gly-Leu-Arg-Lys-Glu-EDANS + H2O
-
 Severe acute respiratory syndrome-related coronavirus DABCYL-Lys-Asn-Ser-Thr-Leu-Gln + Ser-Gly-Leu-Arg-Lys-Glu-EDANS
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.69 SARS-CoV 3CLpro
-
 Severe acute respiratory syndrome-related coronavirus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.22.69 0.0008
-
 iguesterin
-
 Severe acute respiratory syndrome-related coronavirus
3.4.22.69 0.0031
-
 pristimerin
-
 Severe acute respiratory syndrome-related coronavirus
3.4.22.69 0.004
-
 tingenone
-
 Severe acute respiratory syndrome-related coronavirus
3.4.22.69 0.0042
-
 celastrol
-
 Severe acute respiratory syndrome-related coronavirus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.22.69 0.0026
-
-
 Severe acute respiratory syndrome-related coronavirus iguesterin
3.4.22.69 0.0055
-
-
 Severe acute respiratory syndrome-related coronavirus pristimerin
3.4.22.69 0.0099
-
-
 Severe acute respiratory syndrome-related coronavirus tingenone
3.4.22.69 0.0103
-
-
 Severe acute respiratory syndrome-related coronavirus celastrol
3.4.22.69 0.0217
-
-
 Severe acute respiratory syndrome-related coronavirus dihydrocelastrol
3.4.22.69 0.0235
-
-
 Severe acute respiratory syndrome-related coronavirus curcumin