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Literature summary extracted from

  • Prabhakar Reddy, P.; Tiwari, A.K.; Ranga Rao, R.; Madhusudhana, K.; Rama Subba Rao, V.; Ali, A.Z.; Suresh Babu, K.; Madhusudana Rao, J.
    New Labdane diterpenes as intestinal alpha-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes (2009), Bioorg. Med. Chem. Lett., 19, 2562-2565.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.2.1.20 medicine enzyme inhibition as therapeutic target for diabetes, in cancer, viral infections and in lysosomal storage diseases Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.20 (4R,4aR,8aS)-4-[(E)-2-(furan-3-yl)ethenyl]-2-hydroxy-3,4a,8,8-tetramethyl-4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-one
-
Rattus norvegicus
3.2.1.20 (4R,4aR,8aS)-4-[(E)-2-(furan-3-yl)ethenyl]-3,4a,8,8-tetramethyl-1-oxo-1,4,4a,5,6,7,8,8a-octahydronaphthalen-2-yl acetate
-
Rattus norvegicus
3.2.1.20 (4R,4aR,8aS)-4-[(E)-2-(furan-3-yl)ethenyl]-3-(hydroxymethyl)-4a,8,8-trimethyl-4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-one
-
Rattus norvegicus
3.2.1.20 (4S,4aR,8aS)-4-[(E)-2-(furan-3-yl)ethenyl]-3,4a,8,8-tetramethyl-4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-one
-
Rattus norvegicus
3.2.1.20 4-[(E)-2-[(1S,4aS,8aR)-2,5,5,8a-tetramethyl-4-oxo-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]ethenyl]furan-2(5H)-one
-
Rattus norvegicus
3.2.1.20 Hedychia lactone B
-
Rattus norvegicus
3.2.1.20 Spicatanol
-
Rattus norvegicus
3.2.1.20 Spicatanol methyl ether
-
Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.20 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.20 intestine
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.20 4-nitrophenyl alpha-D-glucopyranoside + H2O
-
Rattus norvegicus 4-nitrophenol + alpha-D-glucose
-
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Synonyms

EC Number Synonyms Comment Organism
3.2.1.20 alpha-glucosidase
-
Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.20 additional information
-
0.1 mg/ml, 11.3% enzyme inhibition Rattus norvegicus Hedychia lactone B
3.2.1.20 additional information
-
0.1 mg/ml, 13.5% enzyme inhibition Rattus norvegicus (4R,4aR,8aS)-4-[(E)-2-(furan-3-yl)ethenyl]-2-hydroxy-3,4a,8,8-tetramethyl-4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-one
3.2.1.20 additional information
-
0.1 mg/ml, 15.1% enzyme inhibition Rattus norvegicus (4R,4aR,8aS)-4-[(E)-2-(furan-3-yl)ethenyl]-3-(hydroxymethyl)-4a,8,8-trimethyl-4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-one
3.2.1.20 additional information
-
0.1 mg/ml, 25.7% enzyme inhibition Rattus norvegicus (4R,4aR,8aS)-4-[(E)-2-(furan-3-yl)ethenyl]-3,4a,8,8-tetramethyl-1-oxo-1,4,4a,5,6,7,8,8a-octahydronaphthalen-2-yl acetate
3.2.1.20 additional information
-
0.1 mg/ml, 35.1% enzyme inhibition Rattus norvegicus 4-[(E)-2-[(1S,4aS,8aR)-2,5,5,8a-tetramethyl-4-oxo-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]ethenyl]furan-2(5H)-one
3.2.1.20 additional information
-
0.1 mg/ml, 54.1% enzyme inhibition Rattus norvegicus Spicatanol methyl ether
3.2.1.20 additional information
-
0.1 mg/ml, 55.6% enzyme inhibition Rattus norvegicus (4S,4aR,8aS)-4-[(E)-2-(furan-3-yl)ethenyl]-3,4a,8,8-tetramethyl-4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-one
3.2.1.20 0.0341
-
0.1 mg/ml, 89.5% enzyme inhibition Rattus norvegicus Spicatanol