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Literature summary extracted from

  • Oguro, A.; Sakamoto, K.; Suzuki, S.; Imaoka, S.
    Contribution of hydrolase and phosphatase domains in soluble epoxide hydrolase to vascular endothelial growth factor expression and cell growth (2009), Biol. Pharm. Bull., 32, 1962-1967.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.3.2.10 D335S site-directed mutagensis, the mutant lacks epoxide hydrolase activity. The mutant looses the effects of wild-type sEH on cell growth Homo sapiens
3.3.2.10 D9A site-directed mutagensis, the mutant lacks phosphatase activity. The mutant looses the effects of wild-type sEH on cell growth Homo sapiens
3.3.2.10 additional information knockdown of sEH in He-p3B cells induces the vascular endothelial growth factor, VEGF, mRNA and cell growth, both of which are suppressed by overexpression of sEH in transfected male BALB/c mice Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.10 soluble
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.10 (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 additional information Homo sapiens contribution of hydrolase and phosphatase domains in soluble epoxide hydrolase to vascular endothelial growth factor expression and cell growth, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.10 Homo sapiens P34913
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.10 HEP-3B cell
-
 Homo sapiens
-
3.3.2.10 hepatoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.10 (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 additional information contribution of hydrolase and phosphatase domains in soluble epoxide hydrolase to vascular endothelial growth factor expression and cell growth, overview Homo sapiens ?
-
 ?
3.3.2.10 additional information sEH has phosphatase activity as well as epoxide hydrolase activity Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.10 SEH
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.3.2.10 physiological function sEH plays an important role in the physiology of cells including proliferation. The epoxide hydrolase and phosphatase domains of sEH have different biological functions Homo sapiens