Any feedback?
Literature summary extracted from
- Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation (2010), Biol. Chem., 391, 455-460.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.117 | additional information | KLK7 is activated by proteolytic cleavage through meprin alpha and beta, and through trypsin, overview. Cleavage by meprins enhances activation of LKL7 through trypsin | Homo sapiens | |
| 3.4.24.18 | KLK4 | activator of meprin beta | Homo sapiens | |
| 3.4.24.18 | KLK5 | activator of meprin alpha and beta | Homo sapiens | |
| 3.4.24.18 | KLK8 | activator of meprin beta | Homo sapiens | |
| 3.4.24.18 | additional information | alpha- and beta-tryptase, urokinase plasminogen activator, KLK2, KLK6, KLK7, and KLK11 do not activate meprin alpha and beta | Homo sapiens | |
| 3.4.24.18 | neutrophil elastase | activator of meprin alpha | Homo sapiens | |
| 3.4.24.18 | plasmin | activator of meprin alpha | Homo sapiens | |
| 3.4.24.18 | Trypsin | activator of meprin alpha and beta | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.118 | pefabloc | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.18 | collagen type IV + H2O | Homo sapiens | meprin alpha can degrade collagen type IV | ? | - |
? | |
| 3.4.24.18 | interleukin-1beta + H2O | Homo sapiens | meprin beta activates interleukin 18 | ? | - |
? | |
| 3.4.24.18 | procollagen III + H2O | Homo sapiens | meprin alpha can process procollagen III | ? | - |
? | |
| 3.4.24.18 | tissue growth factor-alpha + H2O | Homo sapiens | meprin alpha can process tissue growth factor-alpha | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.117 | Homo sapiens | - |
- |
- |
| 3.4.21.118 | Homo sapiens | - |
- |
- |
| 3.4.24.18 | Homo sapiens | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.21.117 | proteolytic modification | proKLK7 is processed and activated by meprin metalloproteases alpha and beta, which need to activated themselves by specifically by KLK4, KLK5, and KLK8, overview. Meprins cleave within the N-terminal region of proKLK7. This triggering leads to an accelerated activation of KLK7 (approximately 150%) in the presence of trypsin, overview | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.117 | epidermis | - |
Homo sapiens | - |
| 3.4.21.117 | keratinocyte | - |
Homo sapiens | - |
| 3.4.21.117 | skin | - |
Homo sapiens | - |
| 3.4.21.118 | skin | - |
Homo sapiens | - |
| 3.4.24.18 | epidermis | in human epidermis, meprin alpha is expressed exclusively in the keratinocytes of the stratum basale, whereas meprin beta is restricted to the cells of the stratum granulosum | Homo sapiens | - |
| 3.4.24.18 | skin | in skin, meprins are located in separate layers of human epidermis | Homo sapiens | - |
| 3.4.24.18 | stratum basale | in human epidermis, meprin alpha is expressed exclusively in the keratinocytes of the stratum basale | Homo sapiens | - |
| 3.4.24.18 | stratum granulosum | in human epidermis, meprin beta is restricted to the cells of the stratum granulosum | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.117 | Suc-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Suc-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin | - |
? | |
| 3.4.21.118 | additional information | KLK8 does not degrade and activate promeprin alpha | Homo sapiens | ? | - |
? | |
| 3.4.21.118 | additional information | KLK8 has a strong preference for Arg in P1, and Arg and Lys in P3 position and prefers hydrophobic residues in P2 and small hydrophobic residues in P4 position | Homo sapiens | ? | - |
? | |
| 3.4.21.118 | promeprin beta + H2O | KLK8 activates promeprin beta | Homo sapiens | meprin beta | - |
? | |
| 3.4.24.18 | collagen type IV + H2O | meprin alpha can degrade collagen type IV | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | interleukin-1beta + H2O | meprin beta activates interleukin 18 | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | pro-KLK7 + H2O | meprin beta cleaves pro-KLK7 between Gly17 and Asp18 | Homo sapiens | KLK7 + ? | - |
? | |
| 3.4.24.18 | procollagen III + H2O | meprin alpha can process procollagen III | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | tissue growth factor-alpha + H2O | meprin alpha can process tissue growth factor-alpha | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.117 | KLK7 | - |
Homo sapiens |
| 3.4.21.118 | KLK8 | - |
Homo sapiens |
| 3.4.24.18 | meprin alpha | - |
Homo sapiens |
| 3.4.24.18 | meprin beta | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.24.18 | physiological function | meprin beta induces a dramatic change in cell morphology and a significant reduction in cell number, whereas meprin alpha plays a role for basal keratinocyte proliferation in vitro | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
