EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.15.5 | phylogenetic analysis, expression of His-tagged Dcp in Escherichia coli strain BL21(DE3) | Escherichia coli |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.15.5 | (5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-tryptophan | - |
Escherichia coli | |
3.4.15.5 | captopril | - |
Escherichia coli | |
3.4.15.5 | lisinopril | - |
Escherichia coli | |
3.4.15.5 | lisinopril-Trp | - |
Escherichia coli | |
3.4.15.5 | additional information | inhibition mechanism, molecular modeling, overview | Escherichia coli |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.15.5 | additional information | - |
additional information | kinetics, overview | Escherichia coli | |
3.4.15.5 | 0.00029 | - |
o-aminobenzoyl-FRK(2,4-dinitrophenyl)P-OH | pH 8.0, 37°C, recombinant enzyme | Escherichia coli | |
3.4.15.5 | 0.00066 | - |
o-aminobenzoyl-FRAK(2,4-dinitrophenyl)-OH | pH 8.0, 37°C, recombinant enzyme | Escherichia coli | |
3.4.15.5 | 0.00255 | - |
o-aminobenzoyl-LFK(2,4-dinitrophenyl)-OH | pH 8.0, 37°C, recombinant enzyme | Escherichia coli |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.15.5 | additional information | Escherichia coli | EcDcp removes dipeptides from the free C-termini of peptides, N-blocked tripeptides and unprotected tetrapeptides | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.15.5 | Escherichia coli | P24171 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.15.5 | recombinant His-tagged Dcp from Escherichia coli strain BL21(DE3) by nickel affinity chromatography | Escherichia coli |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.15.5 | angiotensin I + H2O | i.e. DRVYIHPFHL, hydrolysis at the F-H bond generating angiotensin II | Escherichia coli | DRVYIHPF + His-Leu | - |
? | |
3.4.15.5 | bradykinin + H2O | i.e. RPPGFSPFR, hydrolysis at at sequential cleavage sites releasing the C-terminal dipeptides F-R and S-P | Escherichia coli | RPPGF + Ser-Pro + Phe-Arg | - |
? | |
3.4.15.5 | additional information | EcDcp removes dipeptides from the free C-termini of peptides, N-blocked tripeptides and unprotected tetrapeptides | Escherichia coli | ? | - |
? | |
3.4.15.5 | additional information | no activity with Ac-SDKP-OH, o-aminobenzoyl-FRAK(2,4-dinitrophenyl)-NH2, o-aminobenzoyl-SDK(2,4-dinitrophenyl)P-OH and o-aminobenzoyl-APK(2,4-dinitrophenyl)-OH | Escherichia coli | ? | - |
? | |
3.4.15.5 | o-aminobenzoyl-FRAK(2,4-dinitrophenyl)-OH + H2O | an ACE substrate, Dcp hydrolyzes at the R-A bond | Escherichia coli | o-aminobenzoyl-FR + AK(2,4-dinitrophenyl)-OH | - |
? | |
3.4.15.5 | o-aminobenzoyl-FRK(2,4-dinitrophenyl)P-OH + H2O | an ACE substrate, Dcp hydrolyzes at the R-K bond | Escherichia coli | o-aminobenzoyl-FR + K(2,4-dinitrophenyl)P-OH | - |
? | |
3.4.15.5 | o-aminobenzoyl-LFK(2,4-dinitrophenyl)-OH + H2O | an ACE substrate, Dcp hydrolyzes at the L-F bond | Escherichia coli | o-aminobenzoyl-L + FK(2,4-dinitrophenyl)-OH | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.4.15.5 | More | peptide mapping, overview | Escherichia coli |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.15.5 | DCP | - |
Escherichia coli |
3.4.15.5 | Dipeptidyl carboxypeptidase | - |
Escherichia coli |
3.4.15.5 | dipeptidyl carboxypeptidase II | - |
Escherichia coli |
3.4.15.5 | More | the enzyme belongs to the metallopeptidase family M3 | Escherichia coli |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.15.5 | 37 | - |
assay at | Escherichia coli |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.15.5 | 0.81 | - |
o-aminobenzoyl-FRK(2,4-dinitrophenyl)P-OH | pH 8.0, 37°C, recombinant enzyme | Escherichia coli | |
3.4.15.5 | 1.1 | - |
o-aminobenzoyl-FRAK(2,4-dinitrophenyl)-OH | pH 8.0, 37°C, recombinant enzyme | Escherichia coli | |
3.4.15.5 | 1.4 | - |
o-aminobenzoyl-LFK(2,4-dinitrophenyl)-OH | pH 8.0, 37°C, recombinant enzyme | Escherichia coli |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.15.5 | 7.5 | - |
- |
Escherichia coli |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
3.4.15.5 | 4 | 10 | activity range, profile, overview | Escherichia coli |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.15.5 | additional information | - |
additional information | inhibition kinetics, overview | Escherichia coli | |
3.4.15.5 | 0.000003 | - |
captopril | - |
Escherichia coli | |
3.4.15.5 | 0.0008 | - |
lisinopril-Trp | - |
Escherichia coli | |
3.4.15.5 | 0.0044 | - |
lisinopril | - |
Escherichia coli | |
3.4.15.5 | 0.022 | - |
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-tryptophan | - |
Escherichia coli |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.15.5 | 538 | - |
o-aminobenzoyl-LFK(2,4-dinitrophenyl)-OH | pH 8.0, 37°C, recombinant enzyme | Escherichia coli | |
3.4.15.5 | 1667 | - |
o-aminobenzoyl-FRAK(2,4-dinitrophenyl)-OH | pH 8.0, 37°C, recombinant enzyme | Escherichia coli | |
3.4.15.5 | 2793 | - |
o-aminobenzoyl-FRK(2,4-dinitrophenyl)P-OH | pH 8.0, 37°C, recombinant enzyme | Escherichia coli |