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Literature summary extracted from

  • Mailankot, M.; Padmanabha, S.; Pasupuleti, N.; Major, D.; Howell, S.; Nagaraj, R.H.
    Glyoxalase I activity and immunoreactivity in the aging human lens (2009), Biogerontology, 10, 711-720.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.4.1.5 GST-GLOI fusion protein is expressed in Escherichia coli BL21 (DE3)pLysS cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.5 (S)-4-bromobenzylglutathione cyclopentyl diester competitive inhibitor of GLOI Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.4.1.5 cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.4.1.5 methylglyoxal + glutathione Homo sapiens
-
 (R)-S-lactoylglutathione
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.5 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.4.1.5 Ni-NTA resin column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.5 HLE-B3 cell
-
 Homo sapiens
-
4.4.1.5 lens GLOI is mainly localized in the anterior epithelium but the enzyme is diffusely present in outer cortical and nuclear regions of the human lens Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.5 methylglyoxal + glutathione
-
 Homo sapiens (R)-S-lactoylglutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.5 GloI
-
 Homo sapiens
4.4.1.5 glyoxalase I
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.5 glutathione
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
4.4.1.5 Homo sapiens in the human lens, GLOI activity and immunoreactivity both decrease with age down