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Literature summary extracted from

  • Tardy, C.; Sabourdy, F.; Garcia, V.; Jalanko, A.; Therville, N.; Levade, T.; Andrieu-Abadie, N.
    Palmitoyl protein thioesterase 1 modulates tumor necrosis factor alpha-induced apoptosis (2009), Biochim. Biophys. Acta, 1793, 1250-1258.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.2.22 PPT1-deficient fibroblasts stably transfected with cDNA encoding PPT1 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.22 Homo sapiens P50897
-
-
3.1.2.22 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.22 fibroblast normal fibroblasts and infantile neuronal ceroid lipofuscinosis fibroblasts, deficient of PPT1 Homo sapiens
-
3.1.2.22 additional information Ppt1/Cln1-deficient cells Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.22 4-methylumbelliferyl 6-S-palmitoyl-6-thio-beta-D-glucoside + H2O
-
 Mus musculus 4-methylumbelliferyl 6-thio-beta-D-glucoside + palmitate
-
 ?
3.1.2.22 4-methylumbelliferyl 6-S-palmitoyl-6-thio-beta-D-glucoside + H2O
-
 Homo sapiens 4-methylumbelliferyl 6-thio-beta-D-glucoside + palmitate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.2.22 palmitoyl protein thioesterase 1
-
 Mus musculus
3.1.2.22 palmitoyl protein thioesterase 1
-
 Homo sapiens
3.1.2.22 PPT1
-
 Mus musculus
3.1.2.22 PPT1
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.2.22 malfunction PPT1 deficient cells are partially resistant to tumor necrosis factor-induced cell death (57-75% cell viability versus 15-30% for control fibroblasts), tumor necrosis factor-initiated proteolytic cleavage of caspase-8, Bid and caspase-3, as well as cytochrome c release is strongly attenuated. Activation of p42/p44 mitogen-activated protein kinase and of transcription factor NF-kappaB by tumor necrosis factor, and induction of cell death by staurosporine or chemotherapeutic drugs in infantile neuronal ceroid lipofuscinosis cells are unaffected by PPT1 deficiency Homo sapiens
3.1.2.22 malfunction resistance to tumor necrosis factor-induced apoptosis in embryonic fibroblasts derived from Ppt1/Cln1-deficient mice but not from mice with a targeted deletion of Cln3 or Cln5 (murine models of ceroid lipofuscinosis) Mus musculus
3.1.2.22 physiological function role of PPT1 and, likely, protein depalmitoylation in the regulation of tumor necrosis factor-induced apoptosis Mus musculus
3.1.2.22 physiological function role of PPT1 and, likely, protein depalmitoylation in the regulation of tumor necrosis factor-induced apoptosis. PPT1 is involved in cell death triggered by death receptors but not receptor-independent cytotoxic agents. Expression of PPT1 cDNA in infantile neuronal ceroid lipofuscinosis cells restores the tumor necrosis factor sensitivity Homo sapiens