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Literature summary extracted from

  • Brindley, D.N.; Pilquil, C.; Sariahmetoglu, M.; Reue, K.
    Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases (2009), Biochim. Biophys. Acta, 1791, 956-961.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.4 Mg2+ depends on Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Homo sapiens
-
-
-
3.1.3.4 Mus musculus
-
-
-
3.1.3.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.4 3T3-L1 cell lipin-1 and lipin-2 Mus musculus
-
3.1.3.4 fibroblast
-
 Rattus norvegicus
-
3.1.3.4 muscle
-
 Homo sapiens
-
3.1.3.4 preadipocyte cell line lipin-2 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 phosphatidic acid + H2O diacylglycerol is the necessary precursor for the synthesis of triacylglycerols, phosphatidylcholine and phosphatidylethanolamine Mus musculus 1,2-diacyl-sn-glycerol + phosphate
-
 ?
3.1.3.4 phosphatidic acid + H2O diacylglycerol is the necessary precursor for the synthesis of triacylglycerols, phosphatidylcholine and phosphatidylethanolamine Homo sapiens 1,2-diacyl-sn-glycerol + phosphate
-
 ?
3.1.3.4 phosphatidic acid + H2O diacylglycerol is the necessary precursor for the synthesis of triacylglycerols, phosphatidylcholine and phosphatidylethanolamine Rattus norvegicus 1,2-diacyl-sn-glycerol + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.4 lipin-1
-
 Mus musculus
3.1.3.4 lipin-1
-
 Homo sapiens
3.1.3.4 lipin-2
-
 Mus musculus
3.1.3.4 lipin-2
-
 Homo sapiens
3.1.3.4 lipin-3
-
 Mus musculus
3.1.3.4 LPP
-
 Mus musculus
3.1.3.4 LPP
-
 Rattus norvegicus
3.1.3.4 LPP1
-
 Homo sapiens
3.1.3.4 LPP2
-
 Homo sapiens
3.1.3.4 PAP
-
 Mus musculus
3.1.3.4 PAP
-
 Homo sapiens
3.1.3.4 PAP1
-
 Rattus norvegicus
3.1.3.4 phosphatidate phosphatase
-
 Mus musculus
3.1.3.4 phosphatidate phosphatase
-
 Homo sapiens
3.1.3.4 phosphatidate phosphatase
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
3.1.3.4 Mus musculus in the 3T3-L1 cell line, lipin-2 protein levels decline dramatically as adipocyte differentiation proceeds to become virtually undetectable in mature adipocytes, when lipin-1 is expressed at high levels down
3.1.3.4 Mus musculus in the 3T3-L1 cell line, lipin-2 protein levels are highest in preadipocytes up

General Information

EC Number General Information Comment Organism
3.1.3.4 malfunction lipin-1 deficiency causes lipodystrophy, neonatal fatty liver, peripheral neuropathy, insulin resistance, and increased susceptibility to atherosclerosis Mus musculus
3.1.3.4 malfunction lipin-1 deficiency in rare human patients, causes acute myoglobinuria in childhood, does not result in lipodystrophy in these individuals. Muscle sample from a patient with lipin-1 deficiency reveals elevated phosphatidate levels. Rare patients with lipin-2 deficiency have a complex phenotype known as Majeed syndrome, characterized by recurrent osteomyelitis, fever, and anemia Homo sapiens
3.1.3.4 physiological function activation of fibroblasts by lysophosphatidate causes a translocation of Mg2+-dependent PAP activity to the membrane fraction within 2 min when the production of phosphatidic acid and diacylglycerol is increased by lysophosphatidate and platelet-derived growth factor. Translocations of PAP1 activity probably results from the increased presence of phosphatidic acid in membranes Rattus norvegicus
3.1.3.4 physiological function key role for lipin-1 in adipocyte differentiation and lipid biosynthesis Mus musculus
3.1.3.4 physiological function lipin proteins serve an important role in regulating the balance of lipid intermediates, including phosphatidic acid and diacylglycerol, and maintenance of cellular lipid homeostasis Homo sapiens