EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.4 | Arf1 protein | activates PLD2 and PLD1 in vitro | Cricetulus griseus | |
3.1.4.4 | Arf1 protein | activates PLD2 and PLD1 in vitro | Mus musculus | |
3.1.4.4 | Arf1 protein | activates PLD2 and PLD1 in vitro | Homo sapiens | |
3.1.4.4 | Arf1 protein | activates PLD2 and PLD1 in vitro | Rattus norvegicus | |
3.1.4.4 | Arf1 protein | activates PLD2 and PLD1 in vitro | Bos taurus | |
3.1.4.4 | Arf1 protein | activates PLD2 and PLD1 in vitro | Oryctolagus cuniculus | |
3.1.4.4 | Arf4 protein | in 293T cells overexpressing EGFR, Arf4 associates with the cytoplasmic region of EGFR and directly regulates PLD2 activation, but not PLD1 activation | Homo sapiens | |
3.1.4.4 | dynamin | a large GTPase, can interact with PLD in a GTP dependent manner in vitro | Cricetulus griseus | |
3.1.4.4 | dynamin | a large GTPase, can interact with PLD in a GTP dependent manner in vitro | Mus musculus | |
3.1.4.4 | dynamin | a large GTPase, can interact with PLD in a GTP dependent manner in vitro | Homo sapiens | |
3.1.4.4 | dynamin | a large GTPase, can interact with PLD in a GTP dependent manner in vitro | Rattus norvegicus | |
3.1.4.4 | dynamin | a large GTPase, can interact with PLD in a GTP dependent manner in vitro | Bos taurus | |
3.1.4.4 | dynamin | a large GTPase, can interact with PLD in a GTP dependent manner in vitro | Oryctolagus cuniculus | |
3.1.4.4 | additional information | epidermal growth factor triggers the activation of PLD in various cell types, such as a bovine luteal cell line | Bos taurus | |
3.1.4.4 | additional information | epidermal growth factor triggers the activation of PLD in various cell types, such as a Chinese hamster lung fibroblast cell line, CCL39, and a Chinese hamster embryo fibroblast cell line, IIC9 | Cricetulus griseus | |
3.1.4.4 | additional information | epidermal growth factor triggers the activation of PLD in various cell types, such as calvarial osteoblastic cells and 3Y1 rat fibroblasts | Rattus norvegicus | |
3.1.4.4 | additional information | epidermal growth factor triggers the activation of PLD in various cell types, such as immortalized rabbit corneal epithelial cells | Oryctolagus cuniculus | |
3.1.4.4 | additional information | epidermal growth factor triggers the activation of PLD in various cell types, such as mouse embryo fibroblasts, MEFs, a mouse myoblast cell line, C2C12, and a mouse embryo fibroblast cell line Swiss 3T3 | Mus musculus | |
3.1.4.4 | additional information | epidermal growth factor triggers the activation of PLD in various cell types, such as osteoblastic cells, a human embryonic kidney cell line HEK-293, a human epidermoid carcinoma cell line A-431, a human cervical cancer cell line HeLa, and human dermal fibroblasts | Homo sapiens | |
3.1.4.4 | Rac1 | PLD activation by EGF is dependent on Rac1, and not on PKC, in Rat1 fibroblasts | Rattus norvegicus | |
3.1.4.4 | RhoA | mediates PDGF-induced PLD activation in Rat1 fibroblasts | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.4 | additional information | dominant negative Rac1, N17Rac1, completely inhibits PLD activation by EGF, but not by PDGF. Dominant-negative RalA and Ras also abolish PLD activation by EGF | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.4 | phosphatidylcholine + H2O | Cricetulus griseus | - |
choline + phosphatidic acid | - |
? | |
3.1.4.4 | phosphatidylcholine + H2O | Mus musculus | - |
choline + phosphatidic acid | - |
? | |
3.1.4.4 | phosphatidylcholine + H2O | Homo sapiens | - |
choline + phosphatidic acid | - |
? | |
3.1.4.4 | phosphatidylcholine + H2O | Rattus norvegicus | - |
choline + phosphatidic acid | - |
? | |
3.1.4.4 | phosphatidylcholine + H2O | Bos taurus | - |
choline + phosphatidic acid | - |
? | |
3.1.4.4 | phosphatidylcholine + H2O | Oryctolagus cuniculus | - |
choline + phosphatidic acid | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.4 | Bos taurus | - |
isozymes PLD1 and PLD2 | - |
3.1.4.4 | Cricetulus griseus | - |
- |
- |
3.1.4.4 | Homo sapiens | - |
isozymes PLD1 and PLD2 | - |
3.1.4.4 | Mus musculus | - |
isozymes PLD1 and PLD2 | - |
3.1.4.4 | Oryctolagus cuniculus | - |
isozymes PLD2 and PLD1 | - |
3.1.4.4 | Rattus norvegicus | - |
isozymes PLD1 and PLD2 | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.4.4 | 3Y1-B clone 1 cell | fibroblast cell line | Rattus norvegicus | - |
3.1.4.4 | A-431 cell | - |
Homo sapiens | - |
3.1.4.4 | C2C12 cell | - |
Mus musculus | - |
3.1.4.4 | DEDE cell | - |
Cricetulus griseus | - |
3.1.4.4 | epithelial cell | corneal | Oryctolagus cuniculus | - |
3.1.4.4 | fibroblast | - |
Rattus norvegicus | - |
3.1.4.4 | fibroblast | dermal | Homo sapiens | - |
3.1.4.4 | HEK-293 cell | - |
Homo sapiens | - |
3.1.4.4 | HeLa cell | - |
Homo sapiens | - |
3.1.4.4 | IIC9 cell | - |
Cricetulus griseus | - |
3.1.4.4 | lutein cell | - |
Bos taurus | - |
3.1.4.4 | NIH-3T3 cell | - |
Mus musculus | - |
3.1.4.4 | osteoblast | - |
Homo sapiens | - |
3.1.4.4 | osteoblast | calvarial osteoblastic cell | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.4 | phosphatidylcholine + H2O | - |
Cricetulus griseus | choline + phosphatidic acid | - |
? | |
3.1.4.4 | phosphatidylcholine + H2O | - |
Mus musculus | choline + phosphatidic acid | - |
? | |
3.1.4.4 | phosphatidylcholine + H2O | - |
Homo sapiens | choline + phosphatidic acid | - |
? | |
3.1.4.4 | phosphatidylcholine + H2O | - |
Rattus norvegicus | choline + phosphatidic acid | - |
? | |
3.1.4.4 | phosphatidylcholine + H2O | - |
Bos taurus | choline + phosphatidic acid | - |
? | |
3.1.4.4 | phosphatidylcholine + H2O | - |
Oryctolagus cuniculus | choline + phosphatidic acid | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.4 | PLD | - |
Cricetulus griseus |
3.1.4.4 | PLD | - |
Mus musculus |
3.1.4.4 | PLD | - |
Homo sapiens |
3.1.4.4 | PLD | - |
Rattus norvegicus |
3.1.4.4 | PLD | - |
Bos taurus |
3.1.4.4 | PLD | - |
Oryctolagus cuniculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.4.4 | physiological function | roles of phospholipase D in epidermal growth factor receptor, EGFR, signaling, modelling, overview. Coordination of EGF signaling by the PX domain of PLD, detailed overview. PLD is a key mediator of EGFR function, and can be directly regulated by upstream binding partners in an EGF-dependent manner | Cricetulus griseus |
3.1.4.4 | physiological function | roles of phospholipase D in epidermal growth factor receptor, EGFR, signaling, modelling, overview. Coordination of EGF signaling by the PX domain of PLD, detailed overview. PLD is a key mediator of EGFR function, and can be directly regulated by upstream binding partners in an EGF-dependent manner | Mus musculus |
3.1.4.4 | physiological function | roles of phospholipase D in epidermal growth factor receptor, EGFR, signaling, modelling, overview. Coordination of EGF signaling by the PX domain of PLD, detailed overview. PLD is a key mediator of EGFR function, and can be directly regulated by upstream binding partners in an EGF-dependent manner | Homo sapiens |
3.1.4.4 | physiological function | roles of phospholipase D in epidermal growth factor receptor, EGFR, signaling, modelling, overview. Coordination of EGF signaling by the PX domain of PLD, detailed overview. PLD is a key mediator of EGFR function, and can be directly regulated by upstream binding partners in an EGF-dependent manner | Rattus norvegicus |
3.1.4.4 | physiological function | roles of phospholipase D in epidermal growth factor receptor, EGFR, signaling, modelling, overview. Coordination of EGF signaling by the PX domain of PLD, detailed overview. PLD is a key mediator of EGFR function, and can be directly regulated by upstream binding partners in an EGF-dependent manner | Bos taurus |
3.1.4.4 | physiological function | roles of phospholipase D in epidermal growth factor receptor, EGFR, signaling, modelling, overview. Coordination of EGF signaling by the PX domain of PLD, detailed overview. PLD is a key mediator of EGFR function, and can be directly regulated by upstream binding partners in an EGF-dependent manner | Oryctolagus cuniculus |