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Literature summary extracted from

  • Lee, C.S.; Kim, K.L.; Jang, J.H.; Choi, Y.S.; Suh, P.G.; Ryu, S.H.
    The roles of phospholipase D in EGFR signaling (2009), Biochim. Biophys. Acta, 1791, 862-868.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 Arf1 protein activates PLD2 and PLD1 in vitro Cricetulus griseus
3.1.4.4 Arf1 protein activates PLD2 and PLD1 in vitro Mus musculus
3.1.4.4 Arf1 protein activates PLD2 and PLD1 in vitro Homo sapiens
3.1.4.4 Arf1 protein activates PLD2 and PLD1 in vitro Rattus norvegicus
3.1.4.4 Arf1 protein activates PLD2 and PLD1 in vitro Bos taurus
3.1.4.4 Arf1 protein activates PLD2 and PLD1 in vitro Oryctolagus cuniculus
3.1.4.4 Arf4 protein in 293T cells overexpressing EGFR, Arf4 associates with the cytoplasmic region of EGFR and directly regulates PLD2 activation, but not PLD1 activation Homo sapiens
3.1.4.4 dynamin a large GTPase, can interact with PLD in a GTP dependent manner in vitro Cricetulus griseus
3.1.4.4 dynamin a large GTPase, can interact with PLD in a GTP dependent manner in vitro Mus musculus
3.1.4.4 dynamin a large GTPase, can interact with PLD in a GTP dependent manner in vitro Homo sapiens
3.1.4.4 dynamin a large GTPase, can interact with PLD in a GTP dependent manner in vitro Rattus norvegicus
3.1.4.4 dynamin a large GTPase, can interact with PLD in a GTP dependent manner in vitro Bos taurus
3.1.4.4 dynamin a large GTPase, can interact with PLD in a GTP dependent manner in vitro Oryctolagus cuniculus
3.1.4.4 additional information epidermal growth factor triggers the activation of PLD in various cell types, such as a bovine luteal cell line Bos taurus
3.1.4.4 additional information epidermal growth factor triggers the activation of PLD in various cell types, such as a Chinese hamster lung fibroblast cell line, CCL39, and a Chinese hamster embryo fibroblast cell line, IIC9 Cricetulus griseus
3.1.4.4 additional information epidermal growth factor triggers the activation of PLD in various cell types, such as calvarial osteoblastic cells and 3Y1 rat fibroblasts Rattus norvegicus
3.1.4.4 additional information epidermal growth factor triggers the activation of PLD in various cell types, such as immortalized rabbit corneal epithelial cells Oryctolagus cuniculus
3.1.4.4 additional information epidermal growth factor triggers the activation of PLD in various cell types, such as mouse embryo fibroblasts, MEFs, a mouse myoblast cell line, C2C12, and a mouse embryo fibroblast cell line Swiss 3T3 Mus musculus
3.1.4.4 additional information epidermal growth factor triggers the activation of PLD in various cell types, such as osteoblastic cells, a human embryonic kidney cell line HEK-293, a human epidermoid carcinoma cell line A-431, a human cervical cancer cell line HeLa, and human dermal fibroblasts Homo sapiens
3.1.4.4 Rac1 PLD activation by EGF is dependent on Rac1, and not on PKC, in Rat1 fibroblasts Rattus norvegicus
3.1.4.4 RhoA mediates PDGF-induced PLD activation in Rat1 fibroblasts Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 additional information dominant negative Rac1, N17Rac1, completely inhibits PLD activation by EGF, but not by PDGF. Dominant-negative RalA and Ras also abolish PLD activation by EGF Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 phosphatidylcholine + H2O Cricetulus griseus
-
choline + phosphatidic acid
-
?
3.1.4.4 phosphatidylcholine + H2O Mus musculus
-
choline + phosphatidic acid
-
?
3.1.4.4 phosphatidylcholine + H2O Homo sapiens
-
choline + phosphatidic acid
-
?
3.1.4.4 phosphatidylcholine + H2O Rattus norvegicus
-
choline + phosphatidic acid
-
?
3.1.4.4 phosphatidylcholine + H2O Bos taurus
-
choline + phosphatidic acid
-
?
3.1.4.4 phosphatidylcholine + H2O Oryctolagus cuniculus
-
choline + phosphatidic acid
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Bos taurus
-
isozymes PLD1 and PLD2
-
3.1.4.4 Cricetulus griseus
-
-
-
3.1.4.4 Homo sapiens
-
isozymes PLD1 and PLD2
-
3.1.4.4 Mus musculus
-
isozymes PLD1 and PLD2
-
3.1.4.4 Oryctolagus cuniculus
-
isozymes PLD2 and PLD1
-
3.1.4.4 Rattus norvegicus
-
isozymes PLD1 and PLD2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 3Y1-B clone 1 cell fibroblast cell line Rattus norvegicus
-
3.1.4.4 A-431 cell
-
Homo sapiens
-
3.1.4.4 C2C12 cell
-
Mus musculus
-
3.1.4.4 DEDE cell
-
Cricetulus griseus
-
3.1.4.4 epithelial cell corneal Oryctolagus cuniculus
-
3.1.4.4 fibroblast
-
Rattus norvegicus
-
3.1.4.4 fibroblast dermal Homo sapiens
-
3.1.4.4 HEK-293 cell
-
Homo sapiens
-
3.1.4.4 HeLa cell
-
Homo sapiens
-
3.1.4.4 IIC9 cell
-
Cricetulus griseus
-
3.1.4.4 lutein cell
-
Bos taurus
-
3.1.4.4 NIH-3T3 cell
-
Mus musculus
-
3.1.4.4 osteoblast
-
Homo sapiens
-
3.1.4.4 osteoblast calvarial osteoblastic cell Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 phosphatidylcholine + H2O
-
Cricetulus griseus choline + phosphatidic acid
-
?
3.1.4.4 phosphatidylcholine + H2O
-
Mus musculus choline + phosphatidic acid
-
?
3.1.4.4 phosphatidylcholine + H2O
-
Homo sapiens choline + phosphatidic acid
-
?
3.1.4.4 phosphatidylcholine + H2O
-
Rattus norvegicus choline + phosphatidic acid
-
?
3.1.4.4 phosphatidylcholine + H2O
-
Bos taurus choline + phosphatidic acid
-
?
3.1.4.4 phosphatidylcholine + H2O
-
Oryctolagus cuniculus choline + phosphatidic acid
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 PLD
-
Cricetulus griseus
3.1.4.4 PLD
-
Mus musculus
3.1.4.4 PLD
-
Homo sapiens
3.1.4.4 PLD
-
Rattus norvegicus
3.1.4.4 PLD
-
Bos taurus
3.1.4.4 PLD
-
Oryctolagus cuniculus

General Information

EC Number General Information Comment Organism
3.1.4.4 physiological function roles of phospholipase D in epidermal growth factor receptor, EGFR, signaling, modelling, overview. Coordination of EGF signaling by the PX domain of PLD, detailed overview. PLD is a key mediator of EGFR function, and can be directly regulated by upstream binding partners in an EGF-dependent manner Cricetulus griseus
3.1.4.4 physiological function roles of phospholipase D in epidermal growth factor receptor, EGFR, signaling, modelling, overview. Coordination of EGF signaling by the PX domain of PLD, detailed overview. PLD is a key mediator of EGFR function, and can be directly regulated by upstream binding partners in an EGF-dependent manner Mus musculus
3.1.4.4 physiological function roles of phospholipase D in epidermal growth factor receptor, EGFR, signaling, modelling, overview. Coordination of EGF signaling by the PX domain of PLD, detailed overview. PLD is a key mediator of EGFR function, and can be directly regulated by upstream binding partners in an EGF-dependent manner Homo sapiens
3.1.4.4 physiological function roles of phospholipase D in epidermal growth factor receptor, EGFR, signaling, modelling, overview. Coordination of EGF signaling by the PX domain of PLD, detailed overview. PLD is a key mediator of EGFR function, and can be directly regulated by upstream binding partners in an EGF-dependent manner Rattus norvegicus
3.1.4.4 physiological function roles of phospholipase D in epidermal growth factor receptor, EGFR, signaling, modelling, overview. Coordination of EGF signaling by the PX domain of PLD, detailed overview. PLD is a key mediator of EGFR function, and can be directly regulated by upstream binding partners in an EGF-dependent manner Bos taurus
3.1.4.4 physiological function roles of phospholipase D in epidermal growth factor receptor, EGFR, signaling, modelling, overview. Coordination of EGF signaling by the PX domain of PLD, detailed overview. PLD is a key mediator of EGFR function, and can be directly regulated by upstream binding partners in an EGF-dependent manner Oryctolagus cuniculus