EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.21.26 | expression in Rosetta2 cells and in COS-7 cells | Mus musculus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.21.26 | D35A/K196A | reduced specificity for shorter peptides | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.26 | calcitonin gene-related peptide | - |
Mus musculus | |
3.4.21.26 | S17092 | - |
Mus musculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.26 | 0.0012 | - |
calcitonin gene-related peptide | mutant D35A/K196A, shorter peptide of calcitonin gene-related peptide | Mus musculus | |
3.4.21.26 | 0.0034 | - |
calcitonin gene-related peptide | mutant D35A/K196A, diserine mutant of calcitonin gene-related peptide | Mus musculus | |
3.4.21.26 | 0.0043 | - |
calcitonin gene-related peptide | wild type enzyme, full length calcitonin gene-related peptide | Mus musculus | |
3.4.21.26 | 0.01 | - |
calcitonin gene-related peptide | wild type enzyme, shorter peptide of calcitonin gene-related peptide | Mus musculus | |
3.4.21.26 | 0.0125 | - |
calcitonin gene-related peptide | wild type enzyme, diserine mutant of calcitonin gene-related peptide | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.26 | Mus musculus | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.26 | calcitonin gene-related peptide + H2O | assay at pH 7.0, 37°C | Mus musculus | ? | - |
? | |
3.4.21.26 | Substance P + H2O | - |
Mus musculus | ? | - |
? | |
3.4.21.26 | Z-Gly-Pro-7-amido-4-methylcoumarin + H2O | assay at pH 7.0, 37°C | Mus musculus | z-Gly-Pro + 7-amino-4-methylcoumarin | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.26 | PREP | - |
Mus musculus |
3.4.21.26 | prolyl endopeptidase | - |
Mus musculus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.21.26 | 37 | - |
assay at | Mus musculus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.26 | 0.0012 | - |
calcitonin gene-related peptide | wild type enzyme, full length calcitonin gene-related peptide | Mus musculus | |
3.4.21.26 | 0.002 | - |
calcitonin gene-related peptide | wild type enzyme, diserine mutant of calcitonin gene-related peptide | Mus musculus | |
3.4.21.26 | 0.0023 | - |
calcitonin gene-related peptide | mutant D35A/K196A, diserine mutant of calcitonin gene-related peptide | Mus musculus | |
3.4.21.26 | 0.0051 | - |
calcitonin gene-related peptide | mutant D35A/K196A, shorter peptide of calcitonin gene-related peptide | Mus musculus | |
3.4.21.26 | 0.072 | - |
calcitonin gene-related peptide | wild type enzyme, shorter peptide of calcitonin gene-related peptide | Mus musculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.21.26 | 7 | - |
assay at | Mus musculus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.4.21.26 | 0.002 | - |
- |
Mus musculus | calcitonin gene-related peptide |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.26 | 0.16 | - |
calcitonin gene-related peptide | wild type enzyme, diserine mutant of calcitonin gene-related peptide | Mus musculus | |
3.4.21.26 | 0.22 | - |
calcitonin gene-related peptide | mutant D35A/K196A, full length calcitonin gene-related peptide | Mus musculus | |
3.4.21.26 | 0.28 | - |
calcitonin gene-related peptide | wild type enzyme, full length calcitonin gene-related peptide | Mus musculus | |
3.4.21.26 | 0.66 | - |
calcitonin gene-related peptide | mutant D35A/K196A, diserine mutant of calcitonin gene-related peptide | Mus musculus | |
3.4.21.26 | 4.3 | - |
calcitonin gene-related peptide | mutant D35A/K196A, shorter peptide of calcitonin gene-related peptide | Mus musculus | |
3.4.21.26 | 6.9 | - |
calcitonin gene-related peptide | wild type enzyme, shorter peptide of calcitonin gene-related peptide | Mus musculus |