Literature summary extracted from

Rappley, I.; Gitler, A.D.; Selvy, P.E.; LaVoie, M.J.; Levy, B.D.; Brown, H.A.; Lindquist, S.; Selkoe, D.J.
Evidence that alpha-synuclein does not inhibit phospholipase D (2009), Biochemistry, 48, 1077-1083.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.1.4.4	expression of isozymes PLD1b and PLD2a in HEK-293, HeLa, or undifferentiated PC12 cells	Homo sapiens
3.1.4.4	functional overexpression of SPO14 in yeast cells deficient in an essential phosphatidylinositol and phosphatidylcholine transfer protein, i.e. sec14-1/cki1DELTA cells, is not sufficient to rescue the alpha-synuclein-induced growth defect	Saccharomyces cerevisiae

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.4.4	alpha-synuclein	-	Saccharomyces cerevisiae
3.1.4.4	additional information	alpha-synuclein, a small cytosolic protein, does not inhibit phospholipase D	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.1.4.4	membrane	membrane-associated enzyme	Homo sapiens	16020	-

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
3.1.4.4	Ca2+	-	Homo sapiens
3.1.4.4	Mg2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.1.4.4	phosphatidylcholine + H2O	Homo sapiens	-	choline + phosphatidic acid	-	?
3.1.4.4	phosphatidylcholine + H2O	Saccharomyces cerevisiae	-	choline + phosphatidic acid	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.4.4	Homo sapiens	-	isozymes PLD1b and PLD2a	-
3.1.4.4	Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.4.4	phosphatidylcholine + H2O	-	Homo sapiens	choline + phosphatidic acid	-	?
3.1.4.4	phosphatidylcholine + H2O	-	Saccharomyces cerevisiae	choline + phosphatidic acid	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.1.4.4	PLD	-	Homo sapiens
3.1.4.4	PLD	-	Saccharomyces cerevisiae
3.1.4.4	SPO14	-	Saccharomyces cerevisiae

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
3.1.4.4	37	-	assay at	Homo sapiens
3.1.4.4	37	-	assay at	Saccharomyces cerevisiae

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
3.1.4.4	7.5	-	assay at	Homo sapiens
3.1.4.4	7.5	-	assay at	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)