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Literature summary extracted from

  • Nichols, J.D.; Xiang, S.; Schindelin, H.; Rajagopalan, K.V.
    Mutational analysis of Escherichia coli MoeA: two functional activities map to the active site cleft (2007), Biochemistry, 46, 78-86.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.10.1.1 D142N high activity in vitro Escherichia coli
2.10.1.1 D228A wild type activity in vitro Escherichia coli
2.10.1.1 D228N wild type activity in vitro Escherichia coli
2.10.1.1 D259A high activity in vitro Escherichia coli
2.10.1.1 D59A high activity in vitro Escherichia coli
2.10.1.1 D59N high activity in vitro Escherichia coli
2.10.1.1 delPhe53-Arg139 inactive in vivo, low activity in vitro Escherichia coli
2.10.1.1 E188A wild type activity in vitro Escherichia coli
2.10.1.1 E188Q wild type activity in vitro Escherichia coli
2.10.1.1 K275Q decreased activity in vitro Escherichia coli
2.10.1.1 K279Q low activity in vitro Escherichia coli
2.10.1.1 R137Q decreased activity in vitro Escherichia coli
2.10.1.1 R350A low activity in vitro Escherichia coli
2.10.1.1 S271A decreased activity in vitro Escherichia coli
2.10.1.1 S371W low activity in vitro Escherichia coli
2.10.1.1 T100A decreased activity in vitro Escherichia coli
2.10.1.1 T100W decreased activity in vitro Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.10.1.1 adenylyl-molybdopterin + molybdate + 4 H+ Escherichia coli
-
 molybdenum cofactor + AMP + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.10.1.1 Escherichia coli P12281 K-12
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.10.1.1 adenylyl-molybdopterin + molybdate + 4 H+
-
 Escherichia coli molybdenum cofactor + AMP + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.10.1.1 MoeA
-
 Escherichia coli

General Information

EC Number General Information Comment Organism
2.10.1.1 metabolism molybdenum cofactor biosynthesis Escherichia coli