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Literature summary extracted from

  • Takatsume, Y.; Ohdate, T.; Maeta, K.; Nomura, W.; Izawa, S.; Inoue, Y.
    Calcineurin/Crz1 destabilizes Msn2 and Msn4 in the nucleus in response to Ca2+ in Saccharomyces cerevisiae (2010), Biochem. J., 427, 275-287.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.4.1.5 methylglyoxal + glutathione Saccharomyces cerevisiae
-
 (R)-S-lactoylglutathione
-
 ?
4.4.1.5 methylglyoxal + glutathione Saccharomyces cerevisiae YPH250
-
 (R)-S-lactoylglutathione
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.5 Saccharomyces cerevisiae
-
-
-
4.4.1.5 Saccharomyces cerevisiae YPH250
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.5 methylglyoxal + glutathione
-
 Saccharomyces cerevisiae (R)-S-lactoylglutathione
-
 ?
4.4.1.5 methylglyoxal + glutathione
-
 Saccharomyces cerevisiae YPH250 (R)-S-lactoylglutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.5 Glo1
-
 Saccharomyces cerevisiae
4.4.1.5 glyoxalase I
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.5 glutathione
-
 Saccharomyces cerevisiae

Expression

EC Number Organism Comment Expression
4.4.1.5 Saccharomyces cerevisiae the expression of GLO1 is induced following treatment with Ca2+ and is dependent on the mitogen-activated protein kinase Hog1 protein and the Msn2/Msn4 transcription factors, the Ca2+-induced expression of GLO1 is enhanced in the presence of FK506 up