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Literature summary extracted from

  • Burgdorf, C.; Haensel, L.; Heidbreder, M.; Joehren, O.; Schuette, F.; Schunkert, H.; Kurz, T.
    Suppression of cardiac phosphatidate phosphohydrolase 1 activity and lipin mRNA expression in Zucker diabetic fatty rats and humans with type 2 diabetes mellitus (2009), Biochem. Biophys. Res. Commun., 390, 165-170.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.106 Insulin insulin therapy increases both PAP1 activity and lipin mRNA expression in diabetic patients Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.106 Homo sapiens
-
-
-
3.1.3.106 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.106 heart presence of lipin-1 and lipin-3, lipin-2 is absent. Marked differences in cardiac distribution of PAP1 Rattus norvegicus
-
3.1.3.106 left ventricle
-
 Rattus norvegicus
-
3.1.3.106 additional information atrial tissue Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
3.1.3.106 -80°C Homo sapiens
3.1.3.106 -80°C Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.106 1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycero-3-phosphate + H2O
-
 Homo sapiens 1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycerol + phosphate
-
 ?
3.1.3.106 1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycero-3-phosphate + H2O
-
 Rattus norvegicus 1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycerol + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.106 lipin
-
 Homo sapiens
3.1.3.106 lipin
-
 Rattus norvegicus
3.1.3.106 lipin-1
-
 Homo sapiens
3.1.3.106 lipin-1
-
 Rattus norvegicus
3.1.3.106 lipin-3
-
 Homo sapiens
3.1.3.106 lipin-3
-
 Rattus norvegicus
3.1.3.106 PAP1
-
 Homo sapiens
3.1.3.106 PAP1
-
 Rattus norvegicus
3.1.3.106 phosphatidate phosphohydrolase 1
-
 Homo sapiens
3.1.3.106 phosphatidate phosphohydrolase 1
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
3.1.3.106 Homo sapiens atrial lipin-1 and lipin-3 mRNA expression in diabetic patients is 50% and 59% lower as in non-diabetic patients, respectively down
3.1.3.106 Rattus norvegicus PAP1 activity is highly related with cardiac lipin-1 and lipin-3 mRNA expression in Zucker diabetic fatty rats additional information
3.1.3.106 Homo sapiens insulin therapy increases both PAP1 activity and lipin mRNA expression in diabetic patients up
3.1.3.106 Rattus norvegicus left ventricular lipin-1 and lipin-3 expression is 7- to 27fold higher than respective atrial mRNA expression n Zucker diabetic fatty rats up

General Information

EC Number General Information Comment Organism
3.1.3.106 malfunction suppression of cardiac PAP1 activity/lipin expression may contribute to metabolic dysfunction of the diabetic heart Homo sapiens
3.1.3.106 malfunction suppression of cardiac PAP1 activity/lipin expression may contribute to metabolic dysfunction of the diabetic heart Rattus norvegicus
3.1.3.106 physiological function atrial tissue displays PAP1 activity that is 33% lower in those having type 2 diabetes mellitus than in non-diabetic controls Homo sapiens
3.1.3.106 physiological function compared to non-diabetic littermates, left ventricular PAP1 activity is 29% lower in 8-months-old Zucker diabetic fatty rats. Left ventricular PAP1 activities are 2.1fold (diabetic fatty rats) and 3.6fold (non-diabetic rats) higher than the respective atrial activities Rattus norvegicus