EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.17.2 | thrombin | - |
Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.17.2 | antithrombomodulin antibody | - |
Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.17.2 | 65000 | - |
Western blot analysis | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.17.2 | OPN-R + H2O | Homo sapiens | osteopontin (OPN) gets activated by thrombin resulting in OPN-R. OPN-R is subsequently inactivated by CPB generating OPN-L | OPN-L + ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.17.2 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.17.2 | synoviocyte | fibroblast-like synoviocytes | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.17.2 | OPN-R + H2O | osteopontin (OPN) gets activated by thrombin resulting in OPN-R. OPN-R is subsequently inactivated by CPB generating OPN-L | Homo sapiens | OPN-L + ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.17.2 | PcpB | - |
Homo sapiens |
3.4.17.2 | thrombin-activatable fibrinolysis inhibitor | - |
Homo sapiens |
3.4.17.2 | thrombin-activatable procarboxypeptidase B | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.17.2 | physiological function | thrombin-activatable CPB plays a central homeostatic role in rheumatoid arthritis by regulating neutrophil viability and reducing synoviocyte adhesion | Homo sapiens |