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Literature summary extracted from

  • Gao, Q.; Fu, G.; Huang, G.; Lian, X.; Yu, J.; Yang, T.
    Relationship between urokinase plasminogen activator receptor (uPAR) and the invasion of human prenatal hair follicle (2009), Arch. Dermatol. Res., 302, 409-418.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.73 additional information binding of uPA to uPA receptor increases the catalytic efficiency by enhancing its activation by plasmin or other enzymes. uPAR promotes the invasive migration of hair follicles synergizing in manner dependent and independent of uPA during human prenatal morphogenesis Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.73 additional information overexpression of the urokinase-type plasminogen activator N-terminal fragment, uPA ATF, inhibits the combination of uPA receptor and uPA competitively, and the cell invasive migration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.73 plasminogen + H2O Homo sapiens activation plasmin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.73 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.73 epithelial cell outermost epithelial cells of the hair follicle Homo sapiens
-
3.4.21.73 hair follicle uPAR is overexpressed in outer root sheath and interfollicle epidermis, and expressed in the outermost epithelial cells of the hair follicle and the basal keratinocytes of epidermis, the expression decreases with the development of the hair follicle Homo sapiens
-
3.4.21.73 keratinocyte basal keratinocytes of epidermis at the hair follicle. Expression of uPA and uPA receptor is selectively induced at the very tip of the leading edge of the keratinocytes Homo sapiens
-
3.4.21.73 additional information uPA and uPA receptor are expressed during invasive migration of the hair follicle, not under normal circumstances. uPAR promotes the invasive migration of hair follicles synergizing in manner dependent and independent of uPA during human prenatal morphogenesis Homo sapiens
-
3.4.21.73 skin basal keratinocytes of epidermis Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.73 plasminogen + H2O activation Homo sapiens plasmin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.73 uPA
-
 Homo sapiens
3.4.21.73 Urokinase plasminogen activator
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.73 malfunction overexpression of uPAR promotes the invasive migration of hair follicle into the dermis in an uPA-dependent and an uPA-independent, ERK-dependent manner during human prenatal development Homo sapiens
3.4.21.73 physiological function uPA is a potent catalyst of extracellular proteolysis and manifests this action through the conversion of plasminogen into plasmin, which has a range of specificities Homo sapiens