EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.B19 | IkappaBalpha-ubiquitin + H2O | Yersinia sp. | - |
IkappaBalpha + ubiquitin | - |
? | |
3.4.22.B19 | TRAF2-ubiquitin + H2O | Yersinia sp. | - |
TRAF2 + ubiquitin | - |
? | |
3.4.22.B19 | TRAF6-ubiquitin + H2O | Yersinia sp. | - |
TRAF6 + ubiquitin | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.22.B19 | Yersinia sp. | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.B19 | IkappaBalpha-ubiquitin + H2O | - |
Yersinia sp. | IkappaBalpha + ubiquitin | - |
? | |
3.4.22.B19 | additional information | YopH is a tyrosine phosphatase | Yersinia sp. | ? | - |
? | |
3.4.22.B19 | additional information | YopJ uses acetyl-coenzyme A to modify the critical serine and threonine residues in the activation loop of MAPKK6 and thereby blocking phosphorylation | Yersinia sp. | ? | - |
? | |
3.4.22.B19 | TRAF2-ubiquitin + H2O | - |
Yersinia sp. | TRAF2 + ubiquitin | - |
? | |
3.4.22.B19 | TRAF6-ubiquitin + H2O | - |
Yersinia sp. | TRAF6 + ubiquitin | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.22.B19 | Yersinia outer protein | - |
Yersinia sp. |
3.4.22.B19 | YopJ | - |
Yersinia sp. |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.22.B19 | physiological function | YopJ deactivates MAPK- and NF-kappaB signaling pathways, and induces apoptosis of immune cells, YopJ inhibits the c-JNK pathway, attenuates the inflammatory responses, and interferes with the cell apoptotic process. When YopJ is replaced with YopP, the YopP-expressing Yersinia pestis strain exhibits high cytotoxic activity against macrophages | Yersinia sp. |