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Literature summary extracted from

  • Cooper, A.J.; Krasnikov, B.F.; Niatsetskaya, Z.V.; Pinto, J.T.; Callery, P.S.; Villar, M.T.; Artigues, A.; Bruschi, S.A.
    Cysteine S-conjugate beta-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents (2011), Amino Acids, 41, 7-27.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.4.1.13 alpha-keto-gamma-methiolbutyrate
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.4.1.13 cytosol
-
 Rattus norvegicus 5829
-
4.4.1.13 mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.4.1.13 93000
-
 enzyme from rat kidney mitochondrion, most of the activity is present in the low-molecular weight fraction, gel filtration Rattus norvegicus
4.4.1.13 200000
-
 enzyme from rat kidney mitochondrion, some activity is present in the high-molecular weight fraction, gel filtration Rattus norvegicus
4.4.1.13 330000
-
 enzyme from rat kidney cytosol, gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.4.1.13 additional information Rattus norvegicus cysteine S-conjugate beta-lyases catalyze beta-elimination reactions with cysteine S-conjugates that possess a good leaving group in the beta-position. The end products are aminoacrylate and a sulfur-containing fragment. The aminoacrylate tautomerizes and hydrolyzes to pyruvate and ammonia. ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.13 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.13 kidney
-
 Rattus norvegicus
-
4.4.1.13 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.13 (S)-1,1,2,2-tetrafluoroethyl-L-cysteine + H2O
-
 Rattus norvegicus ? + NH3 + pyruvate
-
 ?
4.4.1.13 additional information cysteine S-conjugate beta-lyases catalyze beta-elimination reactions with cysteine S-conjugates that possess a good leaving group in the beta-position. The end products are aminoacrylate and a sulfur-containing fragment. The aminoacrylate tautomerizes and hydrolyzes to pyruvate and ammonia. Rattus norvegicus ?
-
 ?
4.4.1.13 RS-CH2-CH(NH3+)COO- + H2O
-
 Rattus norvegicus RSH + NH3 + pyruvate
-
 ?
4.4.1.13 S-1,2-dichlorovinyl-L-cysteine + H2O
-
 Rattus norvegicus dichlorovinyl mercaptane + NH3 + pyruvate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.13 cysteine S-conjugate beta-lyase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.13 pyridoxal 5'-phosphate pyridoxal 5'-phosphate-containing enzyme Rattus norvegicus