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Literature summary extracted from

  • Kuramoto, E.; Nishiuma, T.; Kobayashi, K.; Yamamoto, M.; Kono, Y.; Funada, Y.; Kotani, Y.; Sisson, T.; Simon, R.; Nishimura, Y.
    Inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model (2009), Am. J. Physiol. Lung Cell Mol. Physiol., 296, L337-L346.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.73 additional information increased plasminogen activator activity in the lung by administering exogenous uPA or by using mice genetically deficient in the uPA inhibitor plasminogen activator inhibitor-1, PAI-1 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.73 plasminogen activator inhibitor-1 an endogenous inhibitor protein, i.e. PAI-1 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.73 additional information Mus musculus inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model, overview. The uPA/plasmin system participates in pericellular proteolysis and is capable of directly degrading matrix components, activating latent proteinases, and activating growth factors ?
-
 ?
3.4.21.73 additional information Mus musculus C57/BL6J inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model, overview. The uPA/plasmin system participates in pericellular proteolysis and is capable of directly degrading matrix components, activating latent proteinases, and activating growth factors ?
-
 ?
3.4.21.73 plasminogen + H2O Mus musculus
-
 plasmin + ?
-
 ?
3.4.21.73 plasminogen + H2O Mus musculus C57/BL6J
-
 plasmin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.73 Mus musculus
-
 C57BL/6J mice
-
3.4.21.73 Mus musculus C57/BL6J
-
 C57BL/6J mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.73 epithelial cell
-
 Mus musculus
-
3.4.21.73 fibroblast
-
 Mus musculus
-
3.4.21.73 lung asthma model mice Mus musculus
-
3.4.21.73 additional information uPA expression analysis in lung, overview Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.73 additional information inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model, overview. The uPA/plasmin system participates in pericellular proteolysis and is capable of directly degrading matrix components, activating latent proteinases, and activating growth factors Mus musculus ?
-
 ?
3.4.21.73 additional information inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model, overview. The uPA/plasmin system participates in pericellular proteolysis and is capable of directly degrading matrix components, activating latent proteinases, and activating growth factors Mus musculus C57/BL6J ?
-
 ?
3.4.21.73 plasminogen + H2O
-
 Mus musculus plasmin + ?
-
 ?
3.4.21.73 plasminogen + H2O
-
 Mus musculus C57/BL6J plasmin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.73 uPA
-
 Mus musculus
3.4.21.73 Urokinase-type plasminogen activator
-
 Mus musculus