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Literature summary extracted from

  • Liu, Y.; Fanburg, B.L.
    Phospholipase D signaling in serotonin-induced mitogenesis of pulmonary artery smooth muscle cells (2008), Am. J. Physiol. Lung Cell Mol. Physiol., 295, L471-L478.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 serotonin i.e. 5-hydroxytryptamine, 5-HT, activates PLD via the 5-HT 2A receptor, leading to the generation of phosphatidic acid that promotes smooth muscle cell proliferation through activations of mammalian target of rapamycin, mTOR, S6K1 and MAPK but not the Rho or PI3-kinase/Akt signaling pathways, overview. Activation is completely blocked by ketanserin Mus musculus
3.1.4.4 serotonin i.e. 5-hydroxytryptamine, 5-HT, activates PLD via the 5-HT 2A receptor, leading to the generation of phosphatidic acid that promotes smooth muscle cell proliferation through activations of mammalian target of rapamycin, mTOR, S6K1 and MAPK but not the Rho or PI3-kinase/Akt signaling pathways, overview. Activation is completely blocked by ketanserin Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.4 overexpression of wild-type and inactive mutant PLD1 in bovine pulmonary artery smooth muscle cells Homo sapiens
3.1.4.4 overexpression of wild-type and inactive mutant PLD2 in bovine pulmonary artery smooth muscle cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.4 K758R catalytically inactive PLD2 mutant Mus musculus
3.1.4.4 K898R catalytically inactive PLD1 mutant Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 phosphatidylcholine + H2O Mus musculus
-
 choline + phosphatidic acid
-
 ?
3.1.4.4 phosphatidylcholine + H2O Homo sapiens
-
 choline + phosphatidic acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Homo sapiens
-
 isozymes PLD1 and PLD2
-
3.1.4.4 Mus musculus
-
 isozymes PLD1 and PLD2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 additional information PLD also performs transphosphatidylation using 1-butanol as phosphatidyl acceptor leading to formation of phosphatidylbutan-1-ol Mus musculus ?
-
 ?
3.1.4.4 additional information PLD also performs transphosphatidylation using 1-butanol as phosphatidyl acceptor leading to formation of phosphatidylbutan-1-ol Homo sapiens ?
-
 ?
3.1.4.4 phosphatidylcholine + H2O
-
 Mus musculus choline + phosphatidic acid
-
 ?
3.1.4.4 phosphatidylcholine + H2O
-
 Homo sapiens choline + phosphatidic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 PLD
-
 Mus musculus
3.1.4.4 PLD
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.4.4 physiological function phospholipase D signaling is involved in serotonin-induced mitogenesis of pulmonary artery smooth muscle cells. PLD activation participates in the cellular proliferation response to serotonin Mus musculus
3.1.4.4 physiological function phospholipase D signaling is involved in serotonin-induced mitogenesis of pulmonary artery smooth muscle cells. PLD activation participates in the cellular proliferation response to serotonin Homo sapiens