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Literature summary extracted from

  • Iwata, M.; Silva Enciso, J.E.; Greenberg, B.H.
    Selective and specific regulation of ectodomain shedding of angiotensin-converting enzyme 2 by tumor necrosis factor alpha-converting enzyme (2009), Am. J. Physiol. Cell Physiol., 297, C1318-C1329.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.17.23 expression in CHO cells Cricetulus griseus
3.4.17.23 expression in E4 cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.17.23 additional information M2-mutant CHO cells, mutated in tumor necrosis factor alpha-converting enzyme, TACE, show reduced shedding of the ectodomain of ACE2 and increased release of the larger soluble enzyme form, compared to the smaller one, overview. Tandem mutation in the juxtamembrane region also causes a decreaee in the small soluble enzyme form Cricetulus griseus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 N-[(1S)-1-carboxy-3-methylbutyl]-3-(3,5-dichlorophenyl)-L-histidine i.e. C16, a ACE2 specific inhibitor Cricetulus griseus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.17.23 membrane ACE2 is a type I membrane-anchored protein with a catalytically active ectodomain, that undergoes shedding Mus musculus 16020
-
3.4.17.23 membrane the larger form of ACE2 is a type I membrane-anchored protein with a catalytically active ectodomain, that undergoes shedding resulting in the smaller soluble enzyme form Cricetulus griseus 16020
-
3.4.17.23 soluble smaller enzyme form without ectodomain Cricetulus griseus
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Cricetulus griseus
-
-
-
3.4.17.23 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.17.23 glycoprotein the lager membraneous and smaller soluble enzyme forms are glycosylated Cricetulus griseus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.23 additional information no activity in CHO cell Cricetulus griseus
-
3.4.17.23 additional information no activity in EC cells Mus musculus
-

Subunits

EC Number Subunits Comment Organism
3.4.17.23 More ACE2 is a type I membrane-anchored protein with a catalytically active ectodomain, that undergoes shedding involving tumor necrosis factor alpha-converting enzyme, TACE Mus musculus
3.4.17.23 More ACE2 is a type I membrane-anchored protein with a catalytically active ectodomain, that undergoes shedding resulting in the smaller soluble enzyme form and involving tumor necrosis factor alpha-converting enzyme, TACE, mechanism, overview Cricetulus griseus

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
 Cricetulus griseus
3.4.17.23 ACE2
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.17.23 37
-
 assay at Cricetulus griseus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.17.23 7.4
-
 assay at Cricetulus griseus

General Information

EC Number General Information Comment Organism
3.4.17.23 physiological function ACE2 is a regulator of the renin-angiotensin system Cricetulus griseus
3.4.17.23 physiological function ACE2 is a regulator of the renin-angiotensin system Mus musculus