Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Luka, Z.
    Methyltetrahydrofolate in folate-binding protein glycine N-methyltransferase (2008), Vitam. Horm., 79, 325-345.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.20
-
 Homo sapiens
2.1.1.20
-
 Rattus norvegicus
2.1.1.20
-
 Oryctolagus cuniculus
2.1.1.20
-
 Mus musculus
2.1.1.20
-
 Sus scrofa

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.1.1.20
-
 Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.20 H176N the mutant activity decreases 25% regarding Vmax Homo sapiens
2.1.1.20 L149P the mutant is inactivated by 90% Homo sapiens
2.1.1.20 N140S the mutant possesses only traces of wild type activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.20 5-methyl-tetrahydrofolate
-
 Homo sapiens
2.1.1.20 5-methyl-tetrahydrofolate
-
 Mus musculus
2.1.1.20 5-methyl-tetrahydrofolate
-
 Oryctolagus cuniculus
2.1.1.20 5-methyl-tetrahydrofolate
-
 Rattus norvegicus
2.1.1.20 5-methyl-tetrahydrofolate
-
 Sus scrofa
2.1.1.20 5-Methyltetrahydrofolate pentaglutamate noncompetitive inhibitor with respect to substrates S-adenosyl-L-methionine and glycine Homo sapiens
2.1.1.20 5-Methyltetrahydrofolate pentaglutamate noncompetitive inhibitor regarding substrates S-adenosyl-L-methionine and glycine Mus musculus
2.1.1.20 5-Methyltetrahydrofolate pentaglutamate noncompetitive inhibitor with respect to substrates S-adenosyl-L-methionine and glycine Oryctolagus cuniculus
2.1.1.20 5-Methyltetrahydrofolate pentaglutamate noncompetitive inhibitor with respect to substrates S-adenosyl-L-methionine and glycine Rattus norvegicus
2.1.1.20 5-Methyltetrahydrofolate pentaglutamate noncompetitive inhibitor with respect to substrates S-adenosyl-L-methionine and glycine Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.20 cytosol
-
 Homo sapiens 5829
-
2.1.1.20 cytosol
-
 Rattus norvegicus 5829
-
2.1.1.20 cytosol
-
 Oryctolagus cuniculus 5829
-
2.1.1.20 cytosol
-
 Mus musculus 5829
-
2.1.1.20 cytosol
-
 Sus scrofa 5829
-
2.1.1.20 nucleus
-
 Homo sapiens 5634
-
2.1.1.20 nucleus
-
 Rattus norvegicus 5634
-
2.1.1.20 nucleus
-
 Oryctolagus cuniculus 5634
-
2.1.1.20 nucleus
-
 Mus musculus 5634
-
2.1.1.20 nucleus
-
 Sus scrofa 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.20 32500
-
 4 * 32500 Homo sapiens
2.1.1.20 32500
-
 4 * 32500 Rattus norvegicus
2.1.1.20 32500
-
 4 * 32500 Oryctolagus cuniculus
2.1.1.20 32500
-
 4 * 32500 Mus musculus
2.1.1.20 32500
-
 4 * 32500 Sus scrofa
2.1.1.20 130000
-
-
 Homo sapiens
2.1.1.20 130000
-
-
 Rattus norvegicus
2.1.1.20 130000
-
-
 Oryctolagus cuniculus
2.1.1.20 130000
-
-
 Mus musculus
2.1.1.20 130000
-
-
 Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.20 Homo sapiens
-
-
-
2.1.1.20 Mus musculus Q9QXF8
-
-
2.1.1.20 Oryctolagus cuniculus
-
-
-
2.1.1.20 Rattus norvegicus
-
-
-
2.1.1.20 Sus scrofa Q29555
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.1.1.20 phosphoprotein GNMT is phosphorylated by cAMP-dependent protein kinase at Ser9, Ser71, Ser139, Ser182, and Ser241 Homo sapiens
2.1.1.20 phosphoprotein GNMT is phosphorylated by cAMP-dependent protein kinase at Ser9, Ser71, Ser139, Ser182, and Ser241 Rattus norvegicus
2.1.1.20 phosphoprotein GNMT is phosphorylated by cAMP-dependent protein kinase at Ser9, Ser71, Ser139, Ser182, and Ser241 Oryctolagus cuniculus
2.1.1.20 phosphoprotein GNMT is phosphorylated by cAMP-dependent protein kinase at Ser9, Ser71, Ser139, Ser182, and Ser241 Sus scrofa

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.20
-
 Homo sapiens
2.1.1.20
-
 Rattus norvegicus
2.1.1.20
-
 Oryctolagus cuniculus
2.1.1.20
-
 Mus musculus
2.1.1.20
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.20 hepatocellular carcinoma cell
-
 Homo sapiens
-
2.1.1.20 hepatocellular carcinoma cell
-
 Mus musculus
-
2.1.1.20 kidney
-
 Homo sapiens
-
2.1.1.20 kidney
-
 Rattus norvegicus
-
2.1.1.20 kidney
-
 Mus musculus
-
2.1.1.20 kidney
-
 Sus scrofa
-
2.1.1.20 liver
-
 Homo sapiens
-
2.1.1.20 liver
-
 Rattus norvegicus
-
2.1.1.20 liver
-
 Oryctolagus cuniculus
-
2.1.1.20 liver
-
 Mus musculus
-
2.1.1.20 liver
-
 Sus scrofa
-
2.1.1.20 additional information no GNMT activity is detected in fetal liver, Novikoff hepatoma cells, Morris hepatoma cells, and Ehrlich ascites cells Homo sapiens
-
2.1.1.20 additional information no GNMT activity is detected in fetal liver, Novikoff hepatoma cells, Morris hepatoma cells, and Ehrlich ascites cells Mus musculus
-
2.1.1.20 pancreas
-
 Homo sapiens
-
2.1.1.20 pancreas
-
 Rattus norvegicus
-
2.1.1.20 pancreas
-
 Mus musculus
-
2.1.1.20 pancreas
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.20 additional information GNMT is phosphorylated by cAMP-dependent protein kinase at Ser9, Ser71, Ser139, Ser182, and Ser241 Mus musculus ?
-
 ?
2.1.1.20 S-adenosyl-L-methionine + glycine
-
 Homo sapiens S-adenosyl-L-homocysteine + N-methylglycine
-
 ?
2.1.1.20 S-adenosyl-L-methionine + glycine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + N-methylglycine
-
 ?
2.1.1.20 S-adenosyl-L-methionine + glycine
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + N-methylglycine
-
 ?
2.1.1.20 S-adenosyl-L-methionine + glycine
-
 Mus musculus S-adenosyl-L-homocysteine + N-methylglycine
-
 ?
2.1.1.20 S-adenosyl-L-methionine + glycine
-
 Sus scrofa S-adenosyl-L-homocysteine + N-methylglycine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.20 homotetramer 4 * 32500 Homo sapiens
2.1.1.20 homotetramer 4 * 32500 Rattus norvegicus
2.1.1.20 homotetramer 4 * 32500 Oryctolagus cuniculus
2.1.1.20 homotetramer 4 * 32500 Mus musculus
2.1.1.20 homotetramer 4 * 32500 Sus scrofa

Synonyms

EC Number Synonyms Comment Organism
2.1.1.20 GNMT
-
 Homo sapiens
2.1.1.20 GNMT
-
 Rattus norvegicus
2.1.1.20 GNMT
-
 Oryctolagus cuniculus
2.1.1.20 GNMT
-
 Mus musculus
2.1.1.20 GNMT
-
 Sus scrofa

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.1.1.20 Rattus norvegicus
-
-
 6.4

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.1.1.20 0.001
-
 at pH 9.0 Rattus norvegicus 5-Methyltetrahydrofolate pentaglutamate
2.1.1.20 0.002
-
 at pH 7.5 Rattus norvegicus 5-Methyltetrahydrofolate pentaglutamate