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Literature summary extracted from
- Metabolism of methimazole by bovine liver microsomal flavine monooxygenase: modulation by imipramine and chlorpromazine, comparison with sheep enzyme (2009), Turk. J. Biochem., 34, 44-50.
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.8 | chlorpromazine | competitively inhibits oxygenation of methimazole by FMO | Bos taurus |  |
| 1.14.13.8 | imipramine | competitively inhibits oxygenation of methimazole by FMO | Bos taurus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.13.8 | 0.11 | - |
Methimazole | pH 8.0, 37°C | Bos taurus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.13.8 | microsome | - |
Bos taurus | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.13.8 | Bos taurus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.13.8 | liver | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.8 | 0.00238 | - |
liver microsomes, substrate methimazole | Bos taurus |
| 1.14.13.8 | 0.00373 | - |
liver microsomes, substrate imipramine | Bos taurus |
| 1.14.13.8 | 0.00375 | - |
liver microsomes, substrate chlorpromazine | Bos taurus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.8 | chlorpromazine + NADPH + H+ + O2 | - |
Bos taurus | chlorpromazine oxide + NADP+ + H2O | - |
? | |
| 1.14.13.8 | imipramine + NADPH + H+ + O2 | - |
Bos taurus | imipramine oxide + NADP+ + H2O | - |
? | |
| 1.14.13.8 | methimazole + NADPH + H+ + O2 | - |
Bos taurus | methimazole S-oxide + NADP+ + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.13.8 | FMO | - |
Bos taurus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.8 | 37 | - |
- |
Bos taurus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.8 | 8 | - |
- |
Bos taurus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.8 | NADPH | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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