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Literature summary extracted from

  • Brown, M.R.; Kornberg, A.
    The long and short of it - polyphosphate, PPK and bacterial survival (2008), Trends Biochem. Sci., 33, 284-290.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.4.1 medicine PPK1 exhibits potential as a target for chemotherapy Klebsiella aerogenes
2.7.4.1 medicine PPK1 exhibits potential as a target for chemotherapy Pseudomonas aeruginosa
2.7.4.1 medicine PPK1 exhibits potential as a target for chemotherapy Dictyostelium discoideum
2.7.4.1 medicine PPK1 exhibits potential as a target for chemotherapy Neisseria meningitidis
2.7.4.1 medicine PPK1 exhibits potential as a target for chemotherapy Bacillus cereus
2.7.4.1 medicine PPK1 exhibits potential as a target for chemotherapy Myxococcus xanthus
2.7.4.1 medicine PPK1 exhibits potential as a target for chemotherapy Helicobacter pylori
2.7.4.1 medicine PPK1 exhibits potential as a target for chemotherapy Bacillus anthracis
2.7.4.1 medicine PPK1 exhibits potential as a target for chemotherapy Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.1 Bacillus anthracis
-
-
-
2.7.4.1 Bacillus cereus
-
-
-
2.7.4.1 Dictyostelium discoideum
-
-
-
2.7.4.1 Escherichia coli P0A7B1
-
-
2.7.4.1 Helicobacter pylori
-
-
-
2.7.4.1 Klebsiella aerogenes
-
-
-
2.7.4.1 Myxococcus xanthus
-
-
-
2.7.4.1 Neisseria meningitidis
-
-
-
2.7.4.1 Pseudomonas aeruginosa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.1 ATP + (phosphate)n
-
 Klebsiella aerogenes ADP + (phosphate)n+1
-
 ?
2.7.4.1 ATP + (phosphate)n
-
 Pseudomonas aeruginosa ADP + (phosphate)n+1
-
 ?
2.7.4.1 ATP + (phosphate)n
-
 Dictyostelium discoideum ADP + (phosphate)n+1
-
 ?
2.7.4.1 ATP + (phosphate)n
-
 Neisseria meningitidis ADP + (phosphate)n+1
-
 ?
2.7.4.1 ATP + (phosphate)n
-
 Bacillus cereus ADP + (phosphate)n+1
-
 ?
2.7.4.1 ATP + (phosphate)n
-
 Myxococcus xanthus ADP + (phosphate)n+1
-
 ?
2.7.4.1 ATP + (phosphate)n
-
 Helicobacter pylori ADP + (phosphate)n+1
-
 ?
2.7.4.1 ATP + (phosphate)n
-
 Bacillus anthracis ADP + (phosphate)n+1
-
 ?
2.7.4.1 ATP + (phosphate)n
-
 Escherichia coli ADP + (phosphate)n+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.4.1 poly P kinase 1
-
 Klebsiella aerogenes
2.7.4.1 poly P kinase 1
-
 Pseudomonas aeruginosa
2.7.4.1 poly P kinase 1
-
 Dictyostelium discoideum
2.7.4.1 poly P kinase 1
-
 Neisseria meningitidis
2.7.4.1 poly P kinase 1
-
 Bacillus cereus
2.7.4.1 poly P kinase 1
-
 Myxococcus xanthus
2.7.4.1 poly P kinase 1
-
 Helicobacter pylori
2.7.4.1 poly P kinase 1
-
 Bacillus anthracis
2.7.4.1 poly P kinase 1
-
 Escherichia coli
2.7.4.1 PPK1
-
 Klebsiella aerogenes
2.7.4.1 PPK1
-
 Pseudomonas aeruginosa
2.7.4.1 PPK1
-
 Dictyostelium discoideum
2.7.4.1 PPK1
-
 Neisseria meningitidis
2.7.4.1 PPK1
-
 Bacillus cereus
2.7.4.1 PPK1
-
 Myxococcus xanthus
2.7.4.1 PPK1
-
 Helicobacter pylori
2.7.4.1 PPK1
-
 Bacillus anthracis
2.7.4.1 PPK1
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.4.1 ATP
-
 Klebsiella aerogenes
2.7.4.1 ATP
-
 Pseudomonas aeruginosa
2.7.4.1 ATP
-
 Dictyostelium discoideum
2.7.4.1 ATP
-
 Neisseria meningitidis
2.7.4.1 ATP
-
 Bacillus cereus
2.7.4.1 ATP
-
 Myxococcus xanthus
2.7.4.1 ATP
-
 Helicobacter pylori
2.7.4.1 ATP
-
 Bacillus anthracis
2.7.4.1 ATP
-
 Escherichia coli

General Information

EC Number General Information Comment Organism
2.7.4.1 malfunction deletion of ppk1 causes loss of virulence for animals Klebsiella aerogenes
2.7.4.1 malfunction deletion of ppk1 causes loss of virulence for animals Pseudomonas aeruginosa
2.7.4.1 malfunction deletion of ppk1 causes loss of virulence for animals Dictyostelium discoideum
2.7.4.1 malfunction deletion of ppk1 causes loss of virulence for animals Neisseria meningitidis
2.7.4.1 malfunction deletion of ppk1 causes loss of virulence for animals Bacillus cereus
2.7.4.1 malfunction deletion of ppk1 causes loss of virulence for animals Myxococcus xanthus
2.7.4.1 malfunction deletion of ppk1 causes loss of virulence for animals Helicobacter pylori
2.7.4.1 malfunction deletion of ppk1 causes loss of virulence for animals Bacillus anthracis
2.7.4.1 malfunction deletion of ppk1 causes loss of virulence for animals Escherichia coli
2.7.4.1 physiological function PPK1 regulates error-prone DNA replication by DNA polymerase IV, leading to adaptive mutation Escherichia coli