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Literature summary extracted from

  • Constantinescu, S.N.; Girardot, M.; Pecquet, C.
    Mining for JAK-STAT mutations in cancer (2008), Trends Biochem. Sci., 33, 122-131.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.10.2 V617F the mutation promotes JAK2 catalytic activation and cytokine-independent signaling Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens O60674 Jak2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 JAK2
-
 Homo sapiens
2.7.10.2 Jak3
-
 Homo sapiens
2.7.10.2 Janus kinase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.2 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.10.2 physiological function constitutive JAK activation leads to persistent activation of STAT transcription factors, and several cancers exhibit constitutive STAT activation, in the absence of JAK or STAT activating mutations Homo sapiens