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Literature summary extracted from

  • Mirzaee, S.; Eriksson, S.; Albertioni, F.
    Differences in cytosolic and mitochondrial 5'-nucleotidase and deoxynucleoside kinase activities in Sprague-Dawley rat and CD-1 mouse tissues: Implication for the toxicity of nucleoside analogs in animal models (2010), Toxicology, 267, 159-164.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.74 cytosol
-
 Mus musculus 5829
-
2.7.1.74 cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.74 Mg2+ required Mus musculus
2.7.1.74 Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.74 ATP + deoxycytidine Mus musculus
-
 ADP + dCMP
-
 ?
2.7.1.74 ATP + deoxycytidine Rattus norvegicus
-
 ADP + dCMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Mus musculus
-
-
-
2.7.1.74 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 adipose tissue
-
 Mus musculus
-
2.7.1.74 adipose tissue
-
 Rattus norvegicus
-
2.7.1.74 biceps
-
 Mus musculus
-
2.7.1.74 biceps
-
 Rattus norvegicus
-
2.7.1.74 brain
-
 Mus musculus
-
2.7.1.74 brain
-
 Rattus norvegicus
-
2.7.1.74 brown adipose tissue
-
 Mus musculus
-
2.7.1.74 brown adipose tissue
-
 Rattus norvegicus
-
2.7.1.74 brown fat
-
 Mus musculus
-
2.7.1.74 brown fat
-
 Rattus norvegicus
-
2.7.1.74 diaphragm
-
 Mus musculus
-
2.7.1.74 diaphragm
-
 Rattus norvegicus
-
2.7.1.74 heart
-
 Mus musculus
-
2.7.1.74 heart
-
 Rattus norvegicus
-
2.7.1.74 heart low enzyme activity Mus musculus
-
2.7.1.74 heart low enzyme activity Rattus norvegicus
-
2.7.1.74 kidney
-
 Mus musculus
-
2.7.1.74 kidney
-
 Rattus norvegicus
-
2.7.1.74 liver
-
 Mus musculus
-
2.7.1.74 liver
-
 Rattus norvegicus
-
2.7.1.74 lung
-
 Mus musculus
-
2.7.1.74 lung
-
 Rattus norvegicus
-
2.7.1.74 additional information enzyme activity tissue distribution analysis, overview Mus musculus
-
2.7.1.74 additional information enzyme activity tissue distribution analysis, overview Rattus norvegicus
-
2.7.1.74 pancreas
-
 Mus musculus
-
2.7.1.74 pancreas
-
 Rattus norvegicus
-
2.7.1.74 semitendinosus
-
 Mus musculus
-
2.7.1.74 semitendinosus
-
 Rattus norvegicus
-
2.7.1.74 skeletal muscle
-
 Mus musculus
-
2.7.1.74 skeletal muscle
-
 Rattus norvegicus
-
2.7.1.74 skeletal muscle low enzyme activity Mus musculus
-
2.7.1.74 skeletal muscle low enzyme activity Rattus norvegicus
-
2.7.1.74 skeletal muscle vastus Mus musculus
-
2.7.1.74 skeletal muscle vastus Rattus norvegicus
-
2.7.1.74 spleen
-
 Mus musculus
-
2.7.1.74 spleen
-
 Rattus norvegicus
-
2.7.1.74 testis
-
 Mus musculus
-
2.7.1.74 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 ATP + 2'-deoxycytidine
-
 Mus musculus ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.74 ATP + 2'-deoxycytidine
-
 Rattus norvegicus ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.74 ATP + deoxycytidine
-
 Mus musculus ADP + dCMP
-
 ?
2.7.1.74 ATP + deoxycytidine
-
 Rattus norvegicus ADP + dCMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
 Mus musculus
2.7.1.74 dCK
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.74 37
-
 assay at Mus musculus
2.7.1.74 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.74 7.6
-
 assay at Mus musculus
2.7.1.74 7.6
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.74 ATP
-
 Mus musculus
2.7.1.74 ATP
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
2.7.1.74 physiological function cytosolic and mitochondrial deoxynucleoside kinases, as well as 5'-deoxynucleotidases, control intracellular and intramitochondrial phosphorylation of natural nucleotides and nucleoside analogs used in antiviral and cancer chemotherapy, overview Mus musculus
2.7.1.74 physiological function cytosolic and mitochondrial deoxynucleoside kinases, as well as 5'-deoxynucleotidases, control intracellular and intramitochondrial phosphorylation of natural nucleotides and nucleoside analogs used in antiviral and cancer chemotherapy, overview Rattus norvegicus