BRENDA - Enzyme Database show

Differences in cytosolic and mitochondrial 5'-nucleotidase and deoxynucleoside kinase activities in Sprague-Dawley rat and CD-1 mouse tissues: Implication for the toxicity of nucleoside analogs in animal models

Mirzaee, S.; Eriksson, S.; Albertioni, F.; Toxicology 267, 159-164 (2010)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.1.74
cytosol
-
Rattus norvegicus
5829
-
2.7.1.74
cytosol
-
Mus musculus
5829
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.1.74
Mg2+
required
Rattus norvegicus
2.7.1.74
Mg2+
required
Mus musculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.74
ATP + deoxycytidine
Mus musculus
-
ADP + dCMP
-
-
?
2.7.1.74
ATP + deoxycytidine
Rattus norvegicus
-
ADP + dCMP
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.74
Mus musculus
-
-
-
2.7.1.74
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
adipose tissue
-
Mus musculus
-
2.7.1.74
adipose tissue
-
Rattus norvegicus
-
2.7.1.74
biceps
-
Mus musculus
-
2.7.1.74
biceps
-
Rattus norvegicus
-
2.7.1.74
brain
-
Mus musculus
-
2.7.1.74
brain
-
Rattus norvegicus
-
2.7.1.74
brown adipose tissue
-
Mus musculus
-
2.7.1.74
brown adipose tissue
-
Rattus norvegicus
-
2.7.1.74
brown fat
-
Mus musculus
-
2.7.1.74
brown fat
-
Rattus norvegicus
-
2.7.1.74
diaphragm
-
Mus musculus
-
2.7.1.74
diaphragm
-
Rattus norvegicus
-
2.7.1.74
heart
; low enzyme activity
Mus musculus
-
2.7.1.74
heart
; low enzyme activity
Rattus norvegicus
-
2.7.1.74
kidney
-
Mus musculus
-
2.7.1.74
kidney
-
Rattus norvegicus
-
2.7.1.74
liver
-
Mus musculus
-
2.7.1.74
liver
-
Rattus norvegicus
-
2.7.1.74
lung
-
Mus musculus
-
2.7.1.74
lung
-
Rattus norvegicus
-
2.7.1.74
additional information
enzyme activity tissue distribution analysis, overview
Mus musculus
-
2.7.1.74
additional information
enzyme activity tissue distribution analysis, overview
Rattus norvegicus
-
2.7.1.74
pancreas
-
Mus musculus
-
2.7.1.74
pancreas
-
Rattus norvegicus
-
2.7.1.74
semitendinosus
-
Mus musculus
-
2.7.1.74
semitendinosus
-
Rattus norvegicus
-
2.7.1.74
skeletal muscle
; low enzyme activity; vastus
Mus musculus
-
2.7.1.74
skeletal muscle
; low enzyme activity; vastus
Rattus norvegicus
-
2.7.1.74
spleen
-
Mus musculus
-
2.7.1.74
spleen
-
Rattus norvegicus
-
2.7.1.74
testis
-
Mus musculus
-
2.7.1.74
testis
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
706844
Mus musculus
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + 2'-deoxycytidine
-
706844
Rattus norvegicus
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + deoxycytidine
-
706844
Mus musculus
ADP + dCMP
-
-
-
?
2.7.1.74
ATP + deoxycytidine
-
706844
Rattus norvegicus
ADP + dCMP
-
-
-
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.7.1.74
37
-
assay at
Mus musculus
2.7.1.74
37
-
assay at
Rattus norvegicus
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.7.1.74
7.6
-
assay at
Mus musculus
2.7.1.74
7.6
-
assay at
Rattus norvegicus
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Rattus norvegicus
2.7.1.74
ATP
-
Mus musculus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Rattus norvegicus
2.7.1.74
ATP
-
Mus musculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.1.74
cytosol
-
Rattus norvegicus
5829
-
2.7.1.74
cytosol
-
Mus musculus
5829
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.1.74
Mg2+
required
Rattus norvegicus
2.7.1.74
Mg2+
required
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.74
ATP + deoxycytidine
Mus musculus
-
ADP + dCMP
-
-
?
2.7.1.74
ATP + deoxycytidine
Rattus norvegicus
-
ADP + dCMP
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
adipose tissue
-
Mus musculus
-
2.7.1.74
adipose tissue
-
Rattus norvegicus
-
2.7.1.74
biceps
-
Mus musculus
-
2.7.1.74
biceps
-
Rattus norvegicus
-
2.7.1.74
brain
-
Mus musculus
-
2.7.1.74
brain
-
Rattus norvegicus
-
2.7.1.74
brown adipose tissue
-
Mus musculus
-
2.7.1.74
brown adipose tissue
-
Rattus norvegicus
-
2.7.1.74
brown fat
-
Mus musculus
-
2.7.1.74
brown fat
-
Rattus norvegicus
-
2.7.1.74
diaphragm
-
Mus musculus
-
2.7.1.74
diaphragm
-
Rattus norvegicus
-
2.7.1.74
heart
; low enzyme activity
Mus musculus
-
2.7.1.74
heart
; low enzyme activity
Rattus norvegicus
-
2.7.1.74
kidney
-
Mus musculus
-
2.7.1.74
kidney
-
Rattus norvegicus
-
2.7.1.74
liver
-
Mus musculus
-
2.7.1.74
liver
-
Rattus norvegicus
-
2.7.1.74
lung
-
Mus musculus
-
2.7.1.74
lung
-
Rattus norvegicus
-
2.7.1.74
additional information
enzyme activity tissue distribution analysis, overview
Mus musculus
-
2.7.1.74
additional information
enzyme activity tissue distribution analysis, overview
Rattus norvegicus
-
2.7.1.74
pancreas
-
Mus musculus
-
2.7.1.74
pancreas
-
Rattus norvegicus
-
2.7.1.74
semitendinosus
-
Mus musculus
-
2.7.1.74
semitendinosus
-
Rattus norvegicus
-
2.7.1.74
skeletal muscle
; low enzyme activity; vastus
Mus musculus
-
2.7.1.74
skeletal muscle
; low enzyme activity; vastus
Rattus norvegicus
-
2.7.1.74
spleen
-
Mus musculus
-
2.7.1.74
spleen
-
Rattus norvegicus
-
2.7.1.74
testis
-
Mus musculus
-
2.7.1.74
testis
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
706844
Mus musculus
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + 2'-deoxycytidine
-
706844
Rattus norvegicus
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + deoxycytidine
-
706844
Mus musculus
ADP + dCMP
-
-
-
?
2.7.1.74
ATP + deoxycytidine
-
706844
Rattus norvegicus
ADP + dCMP
-
-
-
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.7.1.74
37
-
assay at
Mus musculus
2.7.1.74
37
-
assay at
Rattus norvegicus
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.7.1.74
7.6
-
assay at
Mus musculus
2.7.1.74
7.6
-
assay at
Rattus norvegicus
General Information
EC Number
General Information
Commentary
Organism
2.7.1.74
physiological function
cytosolic and mitochondrial deoxynucleoside kinases, as well as 5'-deoxynucleotidases, control intracellular and intramitochondrial phosphorylation of natural nucleotides and nucleoside analogs used in antiviral and cancer chemotherapy, overview
Mus musculus
2.7.1.74
physiological function
cytosolic and mitochondrial deoxynucleoside kinases, as well as 5'-deoxynucleotidases, control intracellular and intramitochondrial phosphorylation of natural nucleotides and nucleoside analogs used in antiviral and cancer chemotherapy, overview
Rattus norvegicus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
2.7.1.74
physiological function
cytosolic and mitochondrial deoxynucleoside kinases, as well as 5'-deoxynucleotidases, control intracellular and intramitochondrial phosphorylation of natural nucleotides and nucleoside analogs used in antiviral and cancer chemotherapy, overview
Mus musculus
2.7.1.74
physiological function
cytosolic and mitochondrial deoxynucleoside kinases, as well as 5'-deoxynucleotidases, control intracellular and intramitochondrial phosphorylation of natural nucleotides and nucleoside analogs used in antiviral and cancer chemotherapy, overview
Rattus norvegicus