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Literature summary extracted from
- An evaluation of the inhibition of human butyrylcholinesterase and acetylcholinesterase by the organophosphate chlorpyrifos oxon (2009), Toxicol. Appl. Pharmacol., 241, 135-142.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.7 | chlorpyrifos oxon | i.e. (O,O-diethyl O-(3,5,6-trichloro-2-pyridyl)) phosphate, an organophosphate | Homo sapiens |  |
| 3.1.1.8 | chlorpyrifos oxon | Michaelis-Menten kinetics, ki: 3048 nM/h, KD: 2.02 nM | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.8 | 0.1 | - |
butyrylthiocholine | incubation of butyrylthiocholine in a concentration range of 0.005-3.0 mM, with 317 pM human butyrylcholinesterase in vitro, Michaelis-Menten kinetics | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.7 | acetylcholine + H2O | Homo sapiens | - |
acetate + choline | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.7 | Homo sapiens | - |
- |
- |
| 3.1.1.8 | Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.7 | acetylcholine + H2O | - |
Homo sapiens | acetate + choline | - |
? | |
| 3.1.1.7 | acetylthiocholine + H2O | - |
Homo sapiens | acetate + thiocholine | - |
? | |
| 3.1.1.8 | butyrylthiocholine + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.7 | AChE | - |
Homo sapiens |
| 3.1.1.7 | More | the enzyme belongs to the superfamily of alpha/beta-hydrolase fold proteins | Homo sapiens |
| 3.1.1.8 | BChE | - |
Homo sapiens |
| 3.1.1.8 | butyrylcholinesterase | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.8 | 24 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.7 | 7.4 | - |
assay at | Homo sapiens |
| 3.1.1.8 | 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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