Literature summary extracted from

Glander, P.; Sombogaard, F.; Budde, K.; van Gelder, T.; Hambach, P.; Liefeldt, L.; Lorkowski, C.; Mai, M.; Neumayer, H.H.; Vulto, A.G.; Mathot, R.A.
Improved assay for the nonradioactive determination of inosine 5-monophosphate dehydrogenase activity in peripheral blood mononuclear cells (2009), Ther. Drug Monit., 31, 351-359.

Application

EC Number	Application	Comment	Organism
1.1.1.205	medicine	modified method for the measurement of IMPDH activity, that is less labor-intensive, more robust in general, and capable of yielding a better reproducibility, which can be used reliably in multicenter trials and in longitudinal studies to evaluate the additional value of any pharmacodynamic monitoring among a diversity of patients treated with mycophenolic acid	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.205	additional information	IMPDH activity decreases more than 10% with increasing contamination by erythrocytes due to increasing AMP and protein content. Storage of lithium heparin blood samples at room temperature for 24 hours before peripheral blood mononuclear cell isolation does not lead to any significant changes in the IMPDH activity, when the activity is normalized to the AMP concentration	Homo sapiens
1.1.1.205	mycophenolate mofetil	-	Homo sapiens
1.1.1.205	Mycophenolic acid	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.205	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.205	peripheral blood mononuclear cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.205	inosine 5'-phosphate + NAD+ + H2O	-	Homo sapiens	xanthosine 5'-phosphate + NADH	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.205	IMPDH	-	Homo sapiens
1.1.1.205	inosine 5'-monophosphate dehydrogenase	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.205	NAD+	-	Homo sapiens

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Release 2023.1 (January 2023)