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Literature summary extracted from

  • Dunn, K.M.; Lee, P.K.; Wilson, C.M.; Iida, J.; Wasiluk, K.R.; Hugger, M.; McCarthy, J.B.
    Inhibition of hyaluronan synthases decreases matrix metalloproteinase-7 (MMP-7) expression and activity (2009), Surgery, 145, 322-329.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.23 semi- and quantitative MMP-7 expression analysis in SW620 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.23 GM6001
-
 Homo sapiens
3.4.24.23 additional information inhibition of hyaluronan synthases HAS2 and HAS3 highly decreases MMP-7 expression and activity in SW620 cells Homo sapiens
3.4.24.23 TIMP-2
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.212 Homo sapiens O00219 isoform HAS3
-
2.4.1.212 Homo sapiens Q92819 isoform HAS2
-
3.4.24.23 Homo sapiens P09237
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.212 SW-620 cell
-
 Homo sapiens
-
3.4.24.23 SW-620 cell colon cancer cell line, high levels of MMP-7 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.4.24.23 Matrix metalloproteinase-7
-
 Homo sapiens
3.4.24.23 MMP-7
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.24.23 Homo sapiens inhibition of hyaluronan synthases HAS2 and HAS3 highly decreases MMP-7 expression and activity in SW620 cells down

General Information

EC Number General Information Comment Organism
2.4.1.212 physiological function inhibition of HAS2 expression by siRNA decreases matrix metalloprotein MMP-7 expression by about 20%, and dramaticlly decreases MMP-7 protein, and enzymatic activity. HAS isoforms and hyaluronan may mediate cellular invasion via changes in matrix metalloprotein MMP-7 expression Homo sapiens
2.4.1.212 physiological function inhibition of HAS2 expression by siRNA decreases matrix metalloprotein MMP-7 expression by about 30%, and dramaticlly decreases MMP-7 protein, and enzymatic activity. HAS isoforms and hyaluronan may mediate cellular invasion via changes in matrix metalloprotein MMP-7 expression Homo sapiens