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Literature summary extracted from

  • Vainchenker, W.; Dusa, A.; Constantinescu, S.N.
    JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies (2008), Semin. Cell Dev. Biol., 19, 385-393.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.10.2 additional information mutations and translocations in the JAK genes leading to constitutively active JAK proteins are associated with a variety of hematopoietic malignancies, including the myeloproliferative disorders (JAK2), acute lymphoblastic leukemia (JAK2), acute myeloid leukemia (JAK2, JAK1), acute megakaryoblastic leukemia (JAK2, JAK3) and T-cell precursor acute lymphoblastic leukemia (JAK1), loss-of-function mutations of JAK3 and TYK2 lead to immunodeficiency Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 Jak1
-
 Homo sapiens
2.7.10.2 JAK2
-
 Homo sapiens
2.7.10.2 Jak3
-
 Homo sapiens
2.7.10.2 Janus kinase
-
 Homo sapiens
2.7.10.2 non-receptor protein tyrosine kinase
-
 Homo sapiens
2.7.10.2 PTK
-
 Homo sapiens
2.7.10.2 Tyk2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.2 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.10.2 physiological function crucial for cytokine receptor signaling in blood formation and immune responses Homo sapiens