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Literature summary extracted from

  • Chen, Y.C.; Kelly, V.P.; Stachura, S.V.; Garcia, G.A.
    Characterization of the human tRNA-guanine transglycosylase: Confirmation of the heterodimeric subunit structure (2010), RNA, 16, 958-968.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.2.64 additional information QTRT1 subunit is responsible for the transglycosylase activity. Transglycosylase activity of QTRT1 is only observed when QTRT1 and QTRTD1 are coexpressed and copurified Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.64 hQTRT1 and ubiquitin-specific protease 14 (USP14) coexpressed in Escherichia coli Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.64 Homo sapiens Q9BXR0
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.64
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.64 [tRNATyr]queuine + guanine human TGT is composed of a catalytic subunit, QTRT1, and QTRTD1, not USP14. QTRTD1 is the salvage enzyme that generates free queuine from QMP Homo sapiens [tRNATyr]-guanine + queuine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.64 heterodimer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.4.2.64 QTRT1
-
 Homo sapiens
2.4.2.64 QTRTD1
-
 Homo sapiens
2.4.2.64 queuine tRNA-ribosyltransferase 1
-
 Homo sapiens
2.4.2.64 queuine tRNA-ribosyltransferase domain-containing 1
-
 Homo sapiens
2.4.2.64 TGT
-
 Homo sapiens
2.4.2.64 tRNA-guanine transglycosylase
-
 Homo sapiens