Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ghanem, M.M.; El-Deeb, W.M.
    Lecithin cholesterol acyltransferase (LCAT) activity as a predictor for ketosis and parturient haemoglobinuria in Egyptian water buffaloes (2010), Res. Vet. Sci., 88, 20-25.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.43 extracellular the enzyme is secreted from liver to blood plasma Bubalus bubalis
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.43 phosphatidylcholine + cholesterol Bubalus bubalis LCAT is a serum enzyme that catalyses esterification of free cholesterol to produce cholesteryl ester. Cholesterol for this reaction comes from peripheral tissues and the donor of the acyl group is lecithin from the high density lipoprotein, HDL, particles cholesteryl ester + lysophosphatidylcholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Bubalus bubalis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.43 blood plasma
-
 Bubalus bubalis
-
2.3.1.43 liver enzyme expression Bubalus bubalis
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.43 additional information
-
 enzyme activity in plasma from healthy buffaloes, and from buffaloes suffering ketosis or haemoglobinuria, overview Bubalus bubalis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 phosphatidylcholine + cholesterol
-
 Bubalus bubalis cholesteryl ester + lysophosphatidylcholine
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol LCAT is a serum enzyme that catalyses esterification of free cholesterol to produce cholesteryl ester. Cholesterol for this reaction comes from peripheral tissues and the donor of the acyl group is lecithin from the high density lipoprotein, HDL, particles Bubalus bubalis cholesteryl ester + lysophosphatidylcholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.43 LCAT
-
 Bubalus bubalis
2.3.1.43 lecithin cholesterol acyltransferase
-
 Bubalus bubalis

General Information

EC Number General Information Comment Organism
2.3.1.43 malfunction LCAT is synthesized in the liver and its synthesis and/or excretion is impaired in hepatocellular diseases as indicated by decreased activity of LCAT, e.g. parturient-haemoglobinuria and ketosis, detection of ketonuria, induced phenotypes, overview Bubalus bubalis
2.3.1.43 physiological function LCAT is necessary for reverse cholesterol transport from peripheral tissues Bubalus bubalis