Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Rajendrasozhan, S.; Hwang, J.W.; Yao, H.; Kishore, N.; Rahman, I.
    Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke (2010), Pulm. Pharmacol. Ther., 23, 172-181.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.11.10 medicine the IKKbeta/IKK2 inhibitor PHA-408 is a powerful anti-inflammatory agent against LPS- and cigarette smoke-mediated lung inflammation Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.10 8-(5-chloro-2-(4-methylpiperazin-1-yl)isonicotinamido)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide PHA-408, ATP-competitive, selective IKK-2 inhibitor Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein] Rattus norvegicus
-
 ADP + [IkappaB phosphoprotein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.10 Rattus norvegicus
-
 adult Sprague-Dawley rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.10 lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein]
-
 Rattus norvegicus ADP + [IkappaB phosphoprotein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.10 IkappaB kinase-beta
-
 Rattus norvegicus
2.7.11.10 IKKbeta
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.10 ATP
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
2.7.11.10 physiological function IkappaB kinase activates NF-kappaB which plays a pivotal role in pro-inflammatory response in the lung Rattus norvegicus