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Literature summary extracted from

  • Hu, R.; Wang, H.; Xia, Z.; Varshavsky, A.
    The N-end rule pathway is a sensor of heme (2008), Proc. Natl. Acad. Sci. USA, 105, 76-81.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.8 hemin Fe3+-heme, inhibits arginyl-transferase through a redox mechanism that involves the formation of disulfide between the enzymes Cys-71 and Cys-72 residues Mus musculus
2.3.2.8 hemin Fe3+-heme, inhibits arginyl-transferase through a redox mechanism that involves the formation of disulfide between the enzymes Cys-71 and Cys-72 residues Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.8 L-arginyl-tRNAArg + protein Mus musculus
-
 tRNAArg + L-arginyl-[protein]
-
 ?
2.3.2.8 L-arginyl-tRNAArg + protein Saccharomyces cerevisiae
-
 tRNAArg + L-arginyl-[protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.8 Mus musculus
-
-
-
2.3.2.8 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.8 L-arginyl-tRNAArg + protein
-
 Mus musculus tRNAArg + L-arginyl-[protein]
-
 ?
2.3.2.8 L-arginyl-tRNAArg + protein
-
 Saccharomyces cerevisiae tRNAArg + L-arginyl-[protein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.8 Arg-tRNA-protein transferase
-
 Mus musculus
2.3.2.8 Arg-tRNA-protein transferase
-
 Saccharomyces cerevisiae
2.3.2.8 arginyl-transferase
-
 Mus musculus
2.3.2.8 arginyl-transferase
-
 Saccharomyces cerevisiae
2.3.2.8 Ate1
-
 Mus musculus
2.3.2.8 Ate1
-
 Saccharomyces cerevisiae
2.3.2.8 R-transferase
-
 Mus musculus
2.3.2.8 R-transferase
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
2.3.2.8 physiological function N-terminal arginylation of intracellular proteins by Arg-tRNA-protein transferase is a part of the N-end rule pathway of protein degradation Mus musculus
2.3.2.8 physiological function N-terminal arginylation of intracellular proteins by Arg-tRNA-protein transferase is a part of the N-end rule pathway of protein degradation Saccharomyces cerevisiae