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Literature summary extracted from

  • Zhang, X.; Bruice, T.C.
    Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases (2008), Proc. Natl. Acad. Sci. USA, 105, 5728-5732.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.364 Y245F the mutation converts the enzyme from a mono- to a dimethyltransferase Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.127 S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine Pisum sativum LSMT transfers two methyl groups to a single lysine S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.127 Pisum sativum
-
-
-
2.1.1.364 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.1.127 3 S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-L-lysine = 3 S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6,N6,N6-trimethyl-L-lysine catalytic reaction mechanism and specificity, molecular dynamics and hybrid quantum mechanics/molecular mechanics, overview Pisum sativum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.127 S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine LSMT transfers two methyl groups to a single lysine Pisum sativum S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine
-
?
2.1.1.364 S-adenosyl-L-methionine + histone H3(K4) SET7/9 only catalyzes the transfer of one methyl group to the target lysine Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.127 Rubisco large-subunit dimethyltransferase
-
Pisum sativum
2.1.1.127 Rubisco LSMT
-
Pisum sativum
2.1.1.127 SET-domain protein lysine methyltransferase
-
Pisum sativum
2.1.1.364 histone lysine methyltransferase
-
Homo sapiens
2.1.1.364 SET-domain protein lysine methyltransferase
-
Homo sapiens
2.1.1.364 SET7/9
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.127 S-adenosyl-L-methionine
-
Pisum sativum