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Literature summary extracted from

  • Gallego-Ortega, D.; Ramirez de Molina, A.; Ramos, M.A.; Valdes-Mora, F.; Barderas, M.G.; Sarmentero-Estrada, J.; Lacal, J.C.
    Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment (2009), PLoS ONE, 4, e7819.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.32 expressed in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.32 choline kinase inhibitor Mn58b
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.32 0.2
-
choline
-
Homo sapiens
2.7.1.32 0.57
-
choline
-
Homo sapiens
2.7.1.32 2.01
-
ethanolamine
-
Homo sapiens
2.7.1.32 12.01
-
ethanolamine
-
Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.32 45000
-
2 * 45000, Western Blot analysis Homo sapiens
2.7.1.32 50000
-
2 * 50000, Western Blot analysis Homo sapiens
2.7.1.32 52000
-
2 * 52000, Western Blot analysis Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.32 Homo sapiens P35790
-
-
2.7.1.32 Homo sapiens Q9Y259
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.32 choline + ATP
-
Homo sapiens phosphocholine + ADP
-
?
2.7.1.32 ethanolamine + ATP
-
Homo sapiens phosphoethanolamine + ADP
-
?

Subunits

EC Number Subunits Comment Organism
2.7.1.32 homodimer 2 * 45000, Western Blot analysis Homo sapiens
2.7.1.32 homodimer 2 * 50000, Western Blot analysis Homo sapiens
2.7.1.32 homodimer 2 * 52000, Western Blot analysis Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.1.32 choline kinase alpha1
-
Homo sapiens
2.7.1.32 choline kinase alpha2
-
Homo sapiens
2.7.1.32 choline kinase beta1
-
Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.32 0.005
-
-
Homo sapiens choline kinase inhibitor Mn58b
2.7.1.32 0.1075
-
-
Homo sapiens choline kinase inhibitor Mn58b