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Literature summary extracted from

  • Gurvitz, A.
    A C. elegans model for mitochondrial fatty acid synthase II: the longevity-associated gene W09H1.5/mecr-1 encodes a 2-trans-enoyl-thioester reductase (2009), PLoS ONE, 4, e7791.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.38 expression in Saccharomyces cerevisiae DELTA etr1 cells Caenorhabditis elegans

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.38 additional information knockdown of MECR-1 resulted in life span extension Caenorhabditis elegans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.38 mitochondrion
-
 Caenorhabditis elegans 5739
-
1.3.1.38 soluble
-
 Caenorhabditis elegans
-
-
2.3.1.85 mitochondrion
-
 Caenorhabditis elegans 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.38 Caenorhabditis elegans O45903
-
-
1.3.1.38 Caenorhabditis elegans Q9XXC8
-
-
2.3.1.85 Caenorhabditis elegans
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.38 0.2
-
 mutant cells over-expressiong MECR-1 Caenorhabditis elegans
1.3.1.38 3.21
-
 cells overexpressing native Etr1p Caenorhabditis elegans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.38 2-trans-hexenoyl-CoA + NADPH
-
 Caenorhabditis elegans ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.38 MECR-1
-
 Caenorhabditis elegans
1.3.1.38 mitochondrial 2-trans-enoyl-CoA/ACP reductase
-
 Caenorhabditis elegans
1.3.1.38 mitochondrial 2-trans-enoyl-thioester reductase
-
 Caenorhabditis elegans
2.3.1.85 FASII
-
 Caenorhabditis elegans
2.3.1.85 fatty acid synthase II
-
 Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
1.3.1.38 malfunction knockdown of MECR-1 resulted in life span extension Caenorhabditis elegans
2.3.1.85 metabolism FASII supplies the C8 substrate for lipoic acid synthesis Caenorhabditis elegans